SARS-CoV-2-cross-reactive T cells identified in pre-pandemic lower airway samples

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Nature Immunology | 2022年 / 23卷 / 9期
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Through access to healthy donors’ bronchoalveolar lavage (BAL) samples cryopreserved before the COVID-19 pandemic, we discovered CD4+ and CD8+ T cells able to cross-recognize SARS-CoV-2 among the airway tissue-resident memory pool. Pre-pandemic donors with detectable SARS-CoV-2-cross-reactive T cells in their airways also had stronger immunity to human seasonal coronaviruses.
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页码：1307 / 1308
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