Synthesis and biocompatibility of porous nano-hydroxyapatite/collagen/alginate composite

被引：0
|
作者：
S. M. Zhang
F. Z. Cui
S. S. Liao
Y. Zhu
L. Han
机构：
[1] Engineering,Department of Materials Science &
[2] Tsinghua University,undefined
来源：
Journal of Materials Science: Materials in Medicine | 2003年 / 14卷
关键词：
Polymer; Mechanical Property; Yield Strength; Alginate; Tissue Engineering;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Porous nano-hydroxyapatite/collagen/alginate (nHAC/Alginate) composite containing nHAC and Ca-crosslinked alginate is synthesized biomimetically. This composite shows a significant improvement in mechanical properties over nHAC material. Mechanical test results show that the compressive modulus and yield strength of this composite are in direct proportion to the percentage of Ca-crosslinked alginate in the composite. Primary biocompatibility experiments in vitro including fibroblasts and osteoblasts co-culture with nHAC/alginate composite indicated the high biocompatibility of this composite. Therefore the composite can be a promising candidate of scaffold material for bone tissue engineering.
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收藏
页码：641 / 645
页数：4
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