Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters

被引：0
|
作者：
Dimitris Kallifidas
Guangde Jiang
Yousong Ding
Hendrik Luesch
机构：
[1] University of Florida,Department of Medicinal Chemistry, College of Pharmacy
[2] University of Florida,Center for Natural Products, Drug Discovery and Development (CNPD3)
来源：
Microbial Cell Factories | / 17卷
关键词：
Secondary metabolism; host engineering; Heterologous expression; Synthetic biology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074
    Jun Tian
    Leixin Ye
    Yuling Yang
    Yalin Zhang
    Changhua Hu
    Guojian Liao
    Science China Life Sciences, 2020, 63 : 1421 - 1424
  • [42] Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074
    Jun Tian
    Leixin Ye
    Yuling Yang
    Yalin Zhang
    Changhua Hu
    Guojian Liao
    Science China(Life Sciences), 2020, 63 (09) : 1421 - 1424
  • [43] Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074
    Jun Tian
    Leixin Ye
    Yuling Yang
    Yalin Zhang
    Changhua Hu
    Guojian Liao
    Science China(Life Sciences), 2020, (09) : 1421 - 1424
  • [44] Unusual site-specific DNA integration into the highly active pseudo-attB of the Streptomyces albus J1074 genome
    Bohdan Bilyk
    Andriy Luzhetskyy
    Applied Microbiology and Biotechnology, 2014, 98 : 5095 - 5104
  • [45] Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2
    Glaser, Lars
    Kuhl, Martin
    Stegmuller, Julian
    Ruckert, Christian
    Myronovskyi, Maksym
    Kalinowski, Jorn
    Luzhetskyy, Andriy
    Wittmann, Christoph
    MICROBIAL CELL FACTORIES, 2021, 20 (01)
  • [46] Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2
    Lars Gläser
    Martin Kuhl
    Julian Stegmüller
    Christian Rückert
    Maksym Myronovskyi
    Jörn Kalinowski
    Andriy Luzhetskyy
    Christoph Wittmann
    Microbial Cell Factories, 20
  • [47] Unusual site-specific DNA integration into the highly active pseudo-attB of the Streptomyces albus J1074 genome
    Bilyk, Bohdan
    Luzhetskyy, Andriy
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 98 (11) : 5095 - 5104
  • [48] Mutations within gene XNR_2147 for TetR-like protein enhance lincomycin resistance and endogenous specialized metabolism of Streptomyces albus J1074
    Tseduliak, Vasylyna-Marta
    Dolia, Borys
    Ostash, Iryna
    Lopatniuk, Maria
    Busche, Tobias
    Ochi, Kozo
    Kalinowski, Joern
    Luzhetskyy, Andriy
    Fedorenko, Victor
    Ostash, Bohdan
    JOURNAL OF APPLIED GENETICS, 2023, 64 (01) : 185 - 195
  • [49] Rational construction of genome-minimized Streptomyces host for the expression of secondary metabolite gene clusters
    Li, Hui
    Gao, Sheng
    Shi, Sanyuan
    Zhao, Xiaomin
    Ye, Haoyu
    Luo, Yunzi
    SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2024, 9 (03) : 600 - 608
  • [50] Mutations within gene XNR_2147 for TetR-like protein enhance lincomycin resistance and endogenous specialized metabolism of Streptomyces albus J1074
    Vasylyna-Marta Tseduliak
    Borys Dolia
    Iryna Ostash
    Maria Lopatniuk
    Tobias Busche
    Kozo Ochi
    Jörn Kalinowski
    Andriy Luzhetskyy
    Victor Fedorenko
    Bohdan Ostash
    Journal of Applied Genetics, 2023, 64 : 185 - 195
12345