Secondary Metabolites Produced by the Deep-Sea-Derived Fungus Engyodontium album

Chemical investigation of the EtOH extract of a rice-fermented deep-sea-derived fungal strain, Engyodontium album, led to the isolation of a new benzoic acid derivative, named engyodontiumin A (1), together with four known compounds, 3,4-dihydroxybenzoic acid (2), 3-(2,4-dihydroxyphenyl) propionic acid (3), 3,4-dimethoxybenzoic acid (4), and trans-4-hydroxycinnamic acid (5). This strain was isolated from a marine sediment sample collected in the Atlantic Ocean (24°23′ W, 0°8′N, 3542 m depth). Their structures were elucidated by spectroscopic analyses, including 1H NMR, 13C NMR, 2D NMR (HSQC, HMBC, COSY), and HR-ESI-MS.