The genetics of chronic obstructive pulmonary disease

被引：0
|
作者：
David A Lomas
Edwin K Silverman
机构：
[1] University of Cambridge,Department of Medicine
[2] Wellcome Trust Centre for Molecular Mechanisms in Disease,undefined
[3] Cambridge Institute for Medical Research,undefined
[4] Brigham and Women's Hospital,undefined
来源：
Respiratory Research | / 2卷
关键词：
association studies; chronic obstructive pulmonary disease; emphysema; genetics; lungs;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.
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