Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells

被引：0
|
作者：
Eleanor O’Brien
Carmen Tse
Ian Tracy
Ian Reddin
Joanna Selfe
Jane Gibson
William Tapper
Reuben J. Pengelly
Jinhui Gao
Ewa Aladowicz
Gemma Petts
Khin Thway
Sergey Popov
Anna Kelsey
Timothy J. Underwood
Janet Shipley
Zoë S. Walters
机构：
[1] The Institute of Cancer Research,Divisions of Molecular Pathology and Cancer Therapeutics
[2] University of Southampton,Cancer Sciences, Faculty of Medicine
[3] University of Southampton,Human Development and Health, Faculty of Medicine
[4] Royal Marsden NHS Foundation Trust,Pathology Department
[5] Cardiff and Vale UHB,Cellular Pathology Department
[6] University of Manchester Foundation Trust,Department of Paediatric Pathology
来源：
Clinical Epigenetics | / 15卷
关键词：
Rhabdomyosarcoma; Differentiation therapy; Epigenetic therapy; EZH2; All-trans retinoic acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Enhancer of Zeste Homolog 2 (ezh2) Inhibition Promotes Lipid Accumulation Independent of Adipogenic Differentiation: Role of Vldl Uptake
    Yiew, Kan Hui N.
    Greenway, Charlotte
    Zarzour, Abdalrahman
    Goo, Brandee
    Tang, Yaoliang
    Chen, Weiqin
    Kim, Ha Won
    Weintraub, Neal L.
    CIRCULATION, 2018, 138
  • [32] Suppression of EZH2 Accelerates MYC-Driven Lymphomagenesis By Inhibition of Apoptosis
    Appelmann, Iris
    Scuoppo, Claudio
    Thapar, Vishal
    Ledezma, Daniela
    Lujambio, Amaia
    Lowe, Scott W.
    Chicas, Agustin
    BLOOD, 2014, 124 (21)
  • [33] EZH2 modulates retinoic acid signaling to ensure myotube formation during development
    Thulabandu, Venkata
    Ferguson, James W.
    Phung, Melissa
    Atit, Radhika P.
    FEBS LETTERS, 2022, 596 (13) : 1672 - 1685
  • [34] Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias
    Poplineau, Mathilde
    Platet, Nadine
    Mazuel, Adrien
    Herault, Leonard
    N'Guyen, Lia
    Koide, Shuhei
    Nakajima-Takagi, Yaeko
    Kuribayashi, Wakako
    Carbuccia, Nadine
    Haboub, Loreen
    Vernerey, Julien
    Oshima, Motohiko
    Birnbaum, Daniel
    Iwama, Atsushi
    Duprez, Estelle
    BLOOD, 2022, 140 (22) : 2358 - 2370
  • [35] Retinoic acid promotes differentiation of trophoblast cells into giant cell
    Yan, JL
    Tanaka, S
    Ohgane, J
    Shiota, K
    MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 523A - 523A
  • [36] Inhibition of EZH2 and EGFR produces a synergistic effect on cell apoptosis by increasing autophagy in gastric cancer cells
    Yang, Youping
    Zhu, Feng
    Wang, Qingmei
    Ding, Yan
    Ying, Rongbiao
    Zeng, Linghui
    ONCOTARGETS AND THERAPY, 2018, 11 : 8455 - 8463
  • [37] Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for human uterine sarcoma cells.
    Omran, Mervat Mostafa
    Vafaei, Somayeh
    Al-Hendy, Ayman
    Yang, Qiwei
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [38] Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2
    Dudakovic, Amel
    Samsonraj, Rebekah M.
    Paradise, Christopher R.
    Galeano-Garces, Catalina
    Mol, Merel O.
    Galeano-Garces, Daniela
    Zan, Pengfei
    Galvan, M. Lizeth
    Hevesi, Mario
    Pichurin, Oksana
    Thaler, Roman
    Begun, Dana L.
    Kloen, Peter
    Karperien, Marcel
    Larson, A. Noelle
    Westendorf, Jennifer J.
    Cool, Simon M.
    van Wijnen, Andre J.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (23) : 7877 - 7893
  • [39] Ezh2 inhibition primes BMP2-mediated osteogenic differentiation and bone healing
    Dudakovic, Amel
    Samsonraj, Rebekah
    Paradise, Christopher
    Galeano-Garces, Catalina
    Mol, Merel
    Galeano-Garces, Daniela
    Galvan, M. Lizeth
    Thaler, Roman
    Larson, A. Noelle
    Westendorf, Jennifer
    van Wijnen, Andre
    Zan, Pengfei
    Begun, Dana
    Kloen, Peter
    Karperien, Marcel
    JOURNAL OF BONE AND MINERAL RESEARCH, 2019, 34 : 229 - 229
  • [40] Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
    Sbirkov, Y.
    Schenk, T.
    Kwok, C.
    Stengel, S.
    Brown, R.
    Brown, G.
    Chesler, L.
    Zelent, A.
    Fuchter, M. J.
    Petrie, K.
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
12345