Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells

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作者
Eleanor O’Brien
Carmen Tse
Ian Tracy
Ian Reddin
Joanna Selfe
Jane Gibson
William Tapper
Reuben J. Pengelly
Jinhui Gao
Ewa Aladowicz
Gemma Petts
Khin Thway
Sergey Popov
Anna Kelsey
Timothy J. Underwood
Janet Shipley
Zoë S. Walters
机构
[1] The Institute of Cancer Research,Divisions of Molecular Pathology and Cancer Therapeutics
[2] University of Southampton,Cancer Sciences, Faculty of Medicine
[3] University of Southampton,Human Development and Health, Faculty of Medicine
[4] Royal Marsden NHS Foundation Trust,Pathology Department
[5] Cardiff and Vale UHB,Cellular Pathology Department
[6] University of Manchester Foundation Trust,Department of Paediatric Pathology
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Rhabdomyosarcoma; Differentiation therapy; Epigenetic therapy; EZH2; All-trans retinoic acid;
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