Optimization and Validation in Liquid Chromatography Using Design of Experiments

被引：0
|
作者：
Latifa Latrous
机构：
[1] Université de Tunis El Manar,Laboratoire de Chimie Minérale Appliquée, Faculté des Sciences de Tunis
[2] Université de Tunis El Manar,Institut Préparatoire Aux Etudes d’Ingénieurs d’El Manar
来源：
Chemistry Africa | 2022年 / 5卷
关键词：
Liquid chromatography; Experimental design; Screening; Optimization; Method validation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Faced to the large number of potential factors in liquid chromatography, the analyst is often led to determine through his experience the parameters to be studied. Experimental designs allow the screening of significant factors and the determination of best experimental conditions for analysis. This review mainly focused on the applications of experimental designs in liquid chromatography method development and validation over the last decades. Key advantages are related to the simultaneous control of a large number of variables to achieve desired separation. Several critical issues like multiple response optimization and modeling with least squares are discussed.
引用
收藏
页码：437 / 458
页数：21
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