Three New Antimicrobial Metabolites of Phomopsis sp.

被引：0
|
作者：
Xiping Du
Chunhua Lu
Yaoyao Li
Zhonghui Zheng
Wenjin Su
Yuemao Shen
机构：
[1] Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering,
[2] Xiamen University,undefined
[3] Xiamen Engineering Research Center of Marine Microbial Drug Discovery,undefined
[4] Xiamen University,undefined
[5] Fujian Engineering Laboratory of Pharmaceuticals,undefined
[6] Xiamen University,undefined
[7] School of Life Sciences,undefined
[8] Xiamen University,undefined
来源：
The Journal of Antibiotics | 2008年 / 61卷
关键词：
10-membered macrolide; benzofuran; sp. hzla01-1; MIC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two new 10-membered macrolides, named Phomolides A (1) and B (2), and one new derivative of benzofuran (3) were isolated from the culture of Phomopsis sp. hzla01-1, and their structures were elucidated based on spectroscopic analyses, particularly 2D NMR experiments. Compounds 1, 2 and 3 showed significant antimicrobial activities against Escherichia coli CMCC44103, Candida albicans AS2.538, Saccharomyces cerevisiae ATCC9763 with MICs 5~10 μg/ml. The most significant, compound 3 showed strong activity against Bacillus subtilis CMCC63501 with the MIC value 1.25 μg/ml. None of the three compounds showed significant cytotoxicity against the HeLa cell line at 10 μg/ml.
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页码：250 / 253
页数：3
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