Synthesis and biological evaluation of new thiazolopyrimidines

被引：0

作者：

Makarem Said

Khaled Abouzid

Ashraf Mouneer

Ali Ahmedy

Abdel Moneim Osman

机构：

[1] Cairo University,Department of Organic Chemistry, Faculty of Pharmacy

[2] Ain-Shams University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy

[3] Cairo University,Department of Microbiology, Faculty of Pharmacy

[4] Cairo University,Pharmacology Unit, NCI

[5] Ain Shams University,Pharmaceutical Chemistry Department, Faculty of Pharmacy

来源：

Archives of Pharmacal Research | 2004年 / 27卷

关键词：

Thiazolopyrimidines; Antimicorbial activity; Antitumor activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In this study, a series of 4-amino-5-cyano-3-substituted-2,3-dihydrothiazol-2-thiones(1a-c), as well as their triazolo and triazinopyrimidine derivatives such as 8-substituted-3-benzyl-5-methylthiazolo [5,4-e][1,2,4] triazolo[1,5-c]pyrimidin-2-thiones(4-6, 10) and 3-benzyl-5-methyl thiazolo [5,4-e]pyrimidino[3,4-b][1,2,4]triazin-2-thiones(7a-b) were prepared as potential antimicrobial and antitumor agents. Some of the tested compounds showed promising antimicrobial activity and non of them showed any appreciable antitumor activity.

引用

页码：471 / 477

页数：6

共 50 条

[41] Structure and Biological Properties of 2-Phenylhydrazone Derivatives of Thiazolopyrimidines
A. S. Agarkov
E. R. Gabitova
F. B. Galieva
A. S. Ovsyannikov
A. D. Voloshina
A. K. Shiryaev
I. A. Litvinov
S. E. Solovieva
I. S. Antipin
Doklady Chemistry, 2022, 503 : 45 - 50
[42] Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity
Nemr, Mohamed T. M.
Sonousi, Amr
Marzouk, Adel A.
BIOORGANIC CHEMISTRY, 2020, 105
[43] Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents
Faisca Phillips, Ana Maria
Barros, Maria Teresa
Pacheco, Marta
Dias, Ricardo
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (01) : 49 - 53
[44] Studies on new substituted pyridazinones: synthesis and biological evaluation
Asif, Nloliaiiimad
Singh, Anita
Khan, Shah Alam
Husain, Asif
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 54 (03)
[45] Synthesis and biological evaluation of new benzofuran carboxamide derivatives
Lavanya, Andiappan
Sribalan, Rajendran
Padmini, Vediappen
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2017, 21 (03) : 277 - 285
[46] Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores
Mathusalini, Sadasivam
Arasakumar, Thangaraj
Lakshmi, Krishnasamy
Lin, Chia-Her
Mohan, Palathurai Subramaniam
Ramnath, Madhusudhanan Gogul
Thirugnanasampandan, Ramaraj
NEW JOURNAL OF CHEMISTRY, 2016, 40 (06) : 5164 - 5169
[47] Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs
Ghosh, Arun K.
Dawson, Zachary L.
Moon, Deuk Kyu
Bai, Ruoli
Hamel, Ernest
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (17) : 5104 - 5107
[48] Synthesis and biological evaluation of new polyaromatic anticancer agents
Bandyopadhyay, Debasish
Short, John
Granados, Chris
Banik, Bimal K.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[49] Synthesis, analysis and biological evaluation of new RGD mimetics
Balacheva, A. A.
Lambev, M. K.
Pashov, I.
Detcheva, R. L.
Sazelova, P.
Momekov, G. Ts.
Kasicka, V.
Pajpanova, T. I.
Golovinsky, E. V.
BULGARIAN CHEMICAL COMMUNICATIONS, 2017, 49 : 7 - 10
[50] Synthesis and biological evaluation of some new coumarinyl thiazolopyrimidinones
Yaragatti, Naazneen B.
Kulkarni, Manohar V.
Ghate, Manjunath D.
Hebbar, Satyanarayan S.
Hegde, Ganesh R.
JOURNAL OF SULFUR CHEMISTRY, 2010, 31 (02) : 123 - 133

← 1 2 3 4 5 →