Synthesis and biological evaluation of new thiazolopyrimidines

被引：0
|
作者：
Makarem Said
Khaled Abouzid
Ashraf Mouneer
Ali Ahmedy
Abdel Moneim Osman
机构：
[1] Cairo University,Department of Organic Chemistry, Faculty of Pharmacy
[2] Ain-Shams University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[3] Cairo University,Department of Microbiology, Faculty of Pharmacy
[4] Cairo University,Pharmacology Unit, NCI
[5] Ain Shams University,Pharmaceutical Chemistry Department, Faculty of Pharmacy
来源：
Archives of Pharmacal Research | 2004年 / 27卷
关键词：
Thiazolopyrimidines; Antimicorbial activity; Antitumor activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, a series of 4-amino-5-cyano-3-substituted-2,3-dihydrothiazol-2-thiones(1a-c), as well as their triazolo and triazinopyrimidine derivatives such as 8-substituted-3-benzyl-5-methylthiazolo [5,4-e][1,2,4] triazolo[1,5-c]pyrimidin-2-thiones(4-6, 10) and 3-benzyl-5-methyl thiazolo [5,4-e]pyrimidino[3,4-b][1,2,4]triazin-2-thiones(7a-b) were prepared as potential antimicrobial and antitumor agents. Some of the tested compounds showed promising antimicrobial activity and non of them showed any appreciable antitumor activity.
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页码：471 / 477
页数：6
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