A novel RNA-binding motif in influenza A virus non-structural protein 1

被引:0
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作者
Chen-ya Chien
Roberto Tejero
Yuanpeng Huang
Diane E. Zimmerman
Carlos B. Ríos
Robert M. Krug
Gaetano T. Montelione
机构
[1] Rutgers University,Center for Advanced Biotechnology and Medicine
[2] Rutgers University,Department of Molecular Biology and Biochemistry
[3] Universidad de Valencia,Departamento de Quimica Fisica
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摘要
The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conserved salt bridges of dimeric NS1(1-73) suggest that the face containing antiparallel helices 2 and 2′ forms a novel arginine-rich nucleic acid binding motif.
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页码:891 / 895
页数:4
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