Genome-wide Analysis of the Expression Profile of Saccharomyces cerevisiae in Response to Treatment with the Plant Isoflavone, Wighteone, as a Potential Antifungal Agent

被引：0

作者：

Hongying Yin

Yongchao Zhao

Yan Zhang

Hongwu Zhang

Lizhen Xu

Zhongmei Zou

Weiping Yang

Jing Cheng

Yuxiang Zhou

机构：

[1] Tsinghua University,Department of Biological Sciences and Biotechnology

[2] Tsinghua University,Medical Systems Biology Research Center, School of Medicine

[3] National Engineering Research Center for Beijing Biochip Technology (NERCBBT),Institute of Medicinal Plants Development

[4] Chinese Academy of Medical Sciences and Peking Union Medical College,undefined

[5] CapitalBio Corporation,undefined

来源：

Biotechnology Letters | 2006年 / 28卷

关键词：

antifungal; microarray; plant extract; wighteone;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs. The antifungal activity of the natural products of a series of plants was evaluated and wighteone, 5, 7, 4′–trihydroxy–6–(γ,γ-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 μg/ml). Transcriptome profiling of wighteone-treated S. cerevisiae indicated that wighteone is different from commonly used antifungal compounds in its mode of action.

引用

页码：99 / 105

页数：6

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