Genome-wide Analysis of the Expression Profile of Saccharomyces cerevisiae in Response to Treatment with the Plant Isoflavone, Wighteone, as a Potential Antifungal Agent

被引：0
|
作者：
Hongying Yin
Yongchao Zhao
Yan Zhang
Hongwu Zhang
Lizhen Xu
Zhongmei Zou
Weiping Yang
Jing Cheng
Yuxiang Zhou
机构：
[1] Tsinghua University,Department of Biological Sciences and Biotechnology
[2] Tsinghua University,Medical Systems Biology Research Center, School of Medicine
[3] National Engineering Research Center for Beijing Biochip Technology (NERCBBT),Institute of Medicinal Plants Development
[4] Chinese Academy of Medical Sciences and Peking Union Medical College,undefined
[5] CapitalBio Corporation,undefined
来源：
Biotechnology Letters | 2006年 / 28卷
关键词：
antifungal; microarray; plant extract; wighteone;
D O I：
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中图分类号：
学科分类号：
摘要：
The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs. The antifungal activity of the natural products of a series of plants was evaluated and wighteone, 5, 7, 4′–trihydroxy–6–(γ,γ-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 μg/ml). Transcriptome profiling of wighteone-treated S. cerevisiae indicated that wighteone is different from commonly used antifungal compounds in its mode of action.
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页码：99 / 105
页数：6
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