LC-MS/MS analysis and pharmacokinetics of daidzein and its 7-O-glucuronide in rats after oral administration of 7-O-L-valyl carbamate prodrug

被引：2
|
作者：
Xu, Xiaolan [1 ]
Li, Yingchao [1 ]
Bai, Xiaochen [2 ]
Lu, Farong [1 ]
Zhang, Yawei [1 ]
Zhang, Tianhong [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Peoples R China
来源：
BIOANALYSIS | 2021年 / 13卷 / 08期
关键词：
bioavailability; carbamate prodrug; daidzein; HPLC-MS/MS; metabolite; pharmacokinetics; CONJUGATIVE METABOLITES; DECOCTION; GENISTEIN; PLASMA; PHYTOESTROGENS; QUANTIFICATION; DISPOSITION; ISOFLAVONES; PRESSURE; PUERARIN;
D O I：
10.4155/bio-2020-0276
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: A valine carbamate prodrug (7-P) was designed to enhance the low bioavailability of daidzein due to its low water solubility and membrane permeability. Here, we developed a high-throughput HPLC-MS/MS method to measure daidzein and its 7-O-glucuronide after oral administration of daidzein or 7-P. Materials & methods: A HPLC-MS/MS method was validated and successfully applied to assess the pharmacokinetic behavior of daidzein and its 7-O-glucuronide after orally administrating daidzein or 7-P. The validated method on selectivity, linearity (r = 0.995), precision (relative standard deviation <11.4%), accuracy (relative error <7.1%), extraction recovery (>92.4%), matrix effect (<8.2%) and stability were satisfied. Conclusion: The proposed economical, rapid and sensitive method will be an alternative analytical procedure for daidzein and its metabolite in biological samples.
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收藏
页码：641 / 653
页数：13
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