Detection and Characteristics of Rifampicin-Resistant Isolates of Mycobacterium tuberculosis

被引：2
|
作者：
Cherednichenko, A. G. [1 ]
Dymova, M. A. [2 ,3 ]
Solodilova, O. A. [4 ]
Petrenko, T. I. [1 ]
Prozorov, A. I. [4 ]
Filipenko, M. L. [2 ,3 ]
机构：
[1] Minist Hlth Russian Federat, Res Inst TB, Novosibirsk, Russia
[2] Russian Acad Sci, Siberian Div, Inst Chem Biol & Fundamental Med, Novosibirsk, Russia
[3] Novosibirsk State Univ, Novosibirsk 630090, Russia
[4] Altai Reg AntiTB Dispensary, Barnaul, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 160卷 / 05期
关键词：
Mycobacterium tuberculosis; drug resistance; rifampicin; rpoB gene;
D O I：
10.1007/s10517-016-3243-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Genotyping and analysis the drug resistance of 59 isolates of M. tuberculosis obtained from patients living in Altai Territory were performed using a BACTEC MGIT 960 fluorometric system by means of VNTR typing (variable number tandem repeat), PCR-RFLP analysis, and sequence analysis. The occurrence frequency was highest for isolates of the Beijing family (n=30, 50.8%). Analysis of mutation spectrum in the rpoB gene associated with rifampicin resistance revealed the major mutation (codon 531 of the rpoB gene) in 93% samples, which allows us to use rapid test systems.
引用
收藏
页码：659 / 663
页数：5
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