Sonochemistry as a General Procedure for the Synthesis of Coumarins, Including Multigram Synthesis

被引：35

作者：

da Silveira Pinto, Ligia S. ^{[1
]}

de Souza, Marcus V. N. ^{[1
,2
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, CP 68563, BR-21945970 Rio De Janeiro, Brazil

[2] FioCruz Fundacao Oswaldo Cruz, Inst Tecnol Farmacos Far Manguinhos, Rua Sizenando Nabuco 100, BR-21041250 Manguinho, RJ, Brazil

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 12期

关键词：

coumarins; sonochemistry; synthesis; multigram scale; smaller scale; ULTRASONIC ASSISTED SYNTHESIS; KNOEVENAGEL; DERIVATIVES;

D O I：

10.1055/s-0036-1590201

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.

引用

页码：2677 / 2682

页数：6

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