Copper-catalyzed enantioselective conjugate addition of diethylzinc using axially chiral aminoethyloxy-phosphine ligands

被引：17

作者：

Morimoto, Toshiaki ^{[1
]}

Obara, Nobuhiro ^{[1
]}

Yoshida, Iku ^{[1
]}

Tanaka, Kiyoshi ^{[1
]}

Kan, Toshiyuki ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Shizuoka 4228526, Japan

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 17期

关键词：

D O I：

10.1016/j.tetlet.2007.02.126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New axially chiral P,O,N-type ligands bearing both a diphenylphosphino group and 2-(dialkylamino) ethyloxy (or 2-pyridylmethyloxy) groups were designed and prepared along with P,O,O-type ligands by employing an easily available chiral component, (R)-2-hydroxy-2'-diphenylphosphinyl-1,1'-binaphthyl. Among the ligands the simplest P,O,N-type one bearing a 2-(dimethylamino)ethyloxy group was found to be the most efficient in copper-catalyzed enantioselective conjugate addition of diethylzine to a cyclic enone, 2-cyclohexen-1-one, providing high enantioselectivity up to 99% ee. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3093 / 3095

页数：3

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