The Role of Ghrelin in Anorexia Nervosa

被引：46
|
作者：
Schalla, Martha A. [1 ,2 ,3 ,4 ]
Stengel, Andreas [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Charite, Dept Psychosomat Med, Charite Ctr Internal Med & Dermatol, D-12203 Berlin, Germany
[2] Free Univ Berlin, D-12203 Berlin, Germany
[3] Humboldt Univ, D-12203 Berlin, Germany
[4] Berlin Inst Hlth, D-12203 Berlin, Germany
[5] Med Univ Hosp Tubingen, Dept Psychosomat Med & Psychotherapy, D-72076 Tubingen, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 07期
关键词：
animal model; body weight; brain-gut axis; drug; eating disorder; food intake; gut-brain axis; hormone; hunger; metabolism; psychosomatic; satiety; DES-ACYL GHRELIN; O-ACYLTRANSFERASE GOAT; GLUCOSE-TOLERANCE TEST; HORMONE SECRETAGOGUE RECEPTOR; FAMILY TRIOS ANALYSIS; BODY-MASS-INDEX; GROWTH-FACTOR-I; PLASMA GHRELIN; RESTRICTING-TYPE; CIRCULATING GHRELIN;
D O I：
10.3390/ijms19072117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ghrelin, a 28-amino acid peptide hormone expressed in X/A-like endocrine cells of the stomach, is the only known peripherally produced and centrally acting peptide that stimulates food intake and therefore attracted a lot of attention with one major focus on the treatment of conditions where an increased energy intake or body weight gain is desired. Anorexia nervosa is an eating disorder characterized by a pronounced reduction of body weight, a disturbed body image and hormonal alterations. Ghrelin signaling has been thoroughly investigated under conditions of anorexia nervosa. The present review will highlight these alterations of ghrelin in anorexia and discuss possible treatment strategies targeting ghrelin signaling. Lastly, gaps in knowledge will be mentioned to foster future research.
引用
收藏
页数：16
相关论文
共 50 条
  • [31] The role of dysregulated ghrelin/LEAP-2 balance in eating disorder: a translational study in anorexia nervosa
    du Montcel, C. Tezenas
    Duriez, P.
    Cao, J.
    Ramoz, N.
    Viltart, O.
    Gorwood, P.
    Tolle, V.
    EUROPEAN PSYCHIATRY, 2023, 66 : S103 - S104
  • [32] Correlations between serum orexins A and B and ghrelin and BMI in anorexia nervosa
    Janas-Kozik, M
    Krupka-Matuszczyk, I
    Krzystanek, M
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2006, 16 : S7 - S8
  • [33] Increased suppression of serum ghrelin concentration by hyperinsulinemia in women with anorexia nervosa
    Karczewska-Kupczewska, Monika
    Straczkowski, Marek
    Adamska, Agnieszka
    Nikolajuk, Agnieszka
    Otziomek, Elzbieta
    Gorska, Maria
    Kowalska, Irina
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2010, 162 (02) : 235 - 239
  • [34] Association Between Ghrelin and Body Weight Trajectory in Individuals With Anorexia Nervosa
    Kim, Youngjung R.
    Lauze, Meghan S.
    Slattery, Meghan
    Perlis, Roy H.
    Holsen, Laura M.
    Breithaupt, Lauren
    Stern, Casey M.
    Fava, Maurizio
    Thomas, Jennifer J.
    Lawson, Elizabeth A.
    Misra, Madhusmita
    Eddy, Kamryn T.
    JAMA NETWORK OPEN, 2023, 6 (03) : E234625
  • [35] Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa
    Janas-Kozik, Malgorzata
    Krupka-Matuszczyk, Irena
    Malinowska-Kolodziej, Izabela
    Lewin-Kowalik, Joanna
    REGULATORY PEPTIDES, 2007, 140 (1-2) : 43 - 46
  • [36] Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents
    Misra, M
    Miller, KK
    Stewart, V
    Hunter, E
    Kuo, K
    Herzog, DB
    Klibanski, A
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (09): : 5082 - 5087
  • [37] Methodological considerations for ghrelin isoforms assay in clinical evaluation in anorexia nervosa
    du Montcel, C. Tezenas
    Duriez, P.
    Lebrun, N.
    Grouselle, D.
    de Grimaudet, B.
    Dardennes, R.
    Epelbaum, J.
    Cuenca, M.
    Viltart, O.
    Gorwood, P.
    Tolle, V.
    COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY, 2022, 11
  • [38] Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents
    Misra, M
    Miller, KK
    Kuo, K
    Griffin, K
    Stewart, V
    Hunter, E
    Herzog, DB
    Klibanski, A
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 289 (02): : E347 - E356
  • [39] Ghrelin levels in obesity and anorexia nervosa:: Effect of weight reduction or recuperation
    Soriano-Guillén, L
    Barrios, V
    Campos-Barros, A
    Argente, J
    JOURNAL OF PEDIATRICS, 2004, 144 (01): : 36 - 42
  • [40] The role of body weight in college students' perceptions of anorexia nervosa and atypical anorexia nervosa
    Meschino, Katherine J.
    Braden, Abby L.
    JOURNAL OF AMERICAN COLLEGE HEALTH, 2024,
12345