Anti-malarial activities of acylated bruceolide derivatives

被引：12
|
作者：
Murakami, N
Umezome, T
Mahmud, T
Sugimoto, M
Kobayashi, M
Wataya, Y
Kim, HS
机构：
[1] Osaka Univ, Fac Pharmaceut Sci, Osaka 565, Japan
[2] Okayama Univ, Fac Pharmaceut Sci, Okayama 700, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(98)00045-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：459 / 462
页数：4
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