MICROWAVE-ASSISTED SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME PYRAZOL-1-YLQUINOXALIN-2(1H)-ONE DERIVATIVES

被引：22
|
作者：
Ajani, Olayinka O. [1 ]
Obafemi, Craig A. [2 ]
Ikpo, Chinwe O. [1 ]
Ogunniran, Kehinde O. [1 ]
Nwinyi, Obinna C. [3 ]
机构：
[1] Covenant Univ, Coll Sci & Technol, Dept Chem, Ota, Ogun State, Nigeria
[2] Obafemi Awolowo Univ, Fac Sci, Dept Chem, Ife, Osun State, Nigeria
[3] Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 11期
关键词：
3-hydrazinoquinoxalin-2(1H)-one; imines; Gram-positive bacteria; ANTIMICROBIAL ACTIVITY; QUINOXALINES;
D O I：
10.1007/s10593-010-0435-z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active with an MIC value of 7.8 mu g/ml.
引用
收藏
页码：1370 / 1378
页数：9
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