Stereotactic Radiosurgery for the Treatment of Recurrent High-grade Gliomas: Long-term Follow-up

被引：5
|
作者：
Sallabanda, Kita [1 ]
Yanez, Loreto [2 ]
Sallabanda, Morena [3 ]
Santos, Marcos [4 ]
Calvo, Felipe A. [5 ]
Marsiglia, Hugo [6 ]
机构：
[1] Hosp Clin Univ San Carlos, Radiosurg Neurosurg, Madrid, Spain
[2] Fdn Arturo Lopez Perez, Radiotherapy, Rancagua, Chile
[3] Hosp Univ Puerta de Hierro, Radiat Oncol, Madrid, Spain
[4] Inst Madrileno Oncol, Neurosurg, Madrid, Spain
[5] Univ Navarra, Radiat Oncol, Madrid, Spain
[6] Fdn Arturo Lopez Perez Santiago de Chile, Radiat Oncol, Santiago, Chile
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2019年 / 11卷 / 12期
关键词：
radiosurgery; cyberknife (R); recurrent gliomas; recurrent gbm; srs; ck-cyberknife; glioblastoma multiforme (gbm); PHASE-II TRIAL; GLIOBLASTOMA-MULTIFORME; EFFICACY; REIRRADIATION; BEVACIZUMAB; ADJUVANT;
D O I：
10.7759/cureus.6527
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
High-grade gliomas (HGG) are the most frequent primary central nervous system tumors; treatment of HCGs includes surgery and post-operative conformal radiotherapy associated with temozolomide (TMZ or procarbazine/lomustine/vincristine [PCV], specifically in patients with anaplastic oligodendrogliomas or anaplastic oligoastrocytomas). However, recurrence is common. Re-irradiation has been utilized in this setting for years and remains a feasible option, although there is always a concern regarding toxicity. Modern high-precision conformal techniques, including stereotactic radiosurgery (SRS), could improve the therapeutic ratio by delivering high biologically equivalent doses while reducing high-dose radiotherapy (RT) to normal brain tissue. In this paper, we present the results obtained after prolonged follow-up in patients who underwent SRS as a treatment for recurrent high-grade gliomas at San Francisco Hospital in Madrid, Spain.
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页数：8
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