Sinucrassins A-K, Casbane-type Diterpenoids from the South China Sea Soft Coral Sinularia crassa

被引：12

作者：

Wu, Meng-Jun ^{[1
,2
,3
]}

Liu, Jiao ^{[3
]}

Wang, Jian-Rong ^{[3
]}

Zhang, Juan ^{[4
]}

Wang, Hong ^{[1
,2
]}

Jiang, Cheng-Shi ^{[4
]}

Guo, Yue-Wei ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

[3] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

[4] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2021年 / 39卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Sinularia crassa; Casbane-type diterpenoid; Configuration determination; X-ray diffraction; NMR spectroscopy; TIXIER-DURIVAULT; IDENTIFICATION; PROSTRATIN; STEROIDS; CASBENE; CLONING;

D O I：

10.1002/cjoc.202100253

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Main observation and conclusion A detailed chemical study on the Hainan soft coral Sinularia crass has resulted in the isolation and characterization of eleven casbane-type diterpenoids, named sinucrassins A-K (1-11), along with six known related ones (12-17). Their structures were elucidated by extensive spectroscopic analyses and comparison with the reported data. The absolute configurations of new compounds were determined by the X-ray diffraction analysis and computer-assisted structural elucidation including C-13 NMR data calculation and time-dependent density functional theory/electronic circular dichroism calculation.

引用

页码：2367 / 2376

页数：10

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