Medical imaging diagnosis of early Alzheimer's disease

被引:8
|
作者
El-Gamal, Fatma El-Zahraa A. [1 ,2 ]
Elmogy, Mohammed M. [1 ,2 ]
Ghazal, Mohammed [2 ,3 ]
Atwan, Ahmed [1 ]
Casanova, Manuel F. [4 ]
Barnes, Gregory N. [5 ]
El-Baz, Ayman S. [2 ]
Hajjdiab, Hassan [3 ]
机构
[1] Mansoura Univ, Fac Comp & Informat, Informat Technol Dept, Mansoura 35516, Egypt
[2] Univ Louisville, BioImaging Lab, Dept Bioengn, Louisville, KY 40292 USA
[3] Abu Dhabi Univ, Dept Elect & Comp Engn, Abu Dhabi, U Arab Emirates
[4] Univ South Carolina, Sch Med, Greenville, SC 29208 USA
[5] Univ Louisville, Autism Ctr, Dept Neurol, Louisville, KY 40217 USA
来源
关键词
Alzheimer's disease; Early Diagnosis; Medical Imaging Modalities; Clinical Findings; Computer-Based Findings; Fusion; Review; MILD COGNITIVE IMPAIRMENT; COMPUTER-AIDED DIAGNOSIS; PRINCIPAL COMPONENT ANALYSIS; PARTIAL LEAST-SQUARES; FDG-PET; FEATURE REPRESENTATION; FEATURE-SELECTION; BRAIN IMAGES; CLASSIFICATION; BIOMARKERS;
D O I
10.2741/4612
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases that influences the central nervous system, often leading to dire consequences for quality of life. The disease goes through some stages mainly divided into early, moderate, and severe. Among them, the early stage is the most important as medical intervention has the potential to alter the natural progression of the condition. In practice, the early diagnosis is a challenge since the neurodegenerative changes can precede the onset of clinical symptoms by 10-15 years. This factor along with other known and unknown ones, hinder the ability for the early diagnosis and treatment of AD. Numerous research efforts have been proposed to address the complex characteristics of AD exploiting various tests including brain imaging that is massively utilized due to its powerful features. This paper aims to highlight our present knowledge on the clinical and computer-based attempts at early diagnosis of AD. We concluded that the door is still open for further research especially with the rapid advances in scanning and computer-based technologies.
引用
收藏
页码:671 / 725
页数:55
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