Positive Lymphocytotoxic Crossmatch Does Not Adversely Affect Survival in Living Donor Liver Transplantation

被引：18
|
作者：
Sugawara, Yasuhiko [1 ]
Tamura, Sumihito [1 ]
Kaneko, Junichi [1 ]
Togashi, Junichi [1 ]
Makuuchi, Masatoshi [1 ]
Kokudo, Norihiro [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Artificial Organ & Transplantat Div, Dept Surg,Bunkyo Ku, Tokyo 1138655, Japan
来源：
DIGESTIVE SURGERY | 2009年 / 26卷 / 06期
关键词：
Acute rejection; Living donor liver transplantation; Preformed antibodies; HEPATIC ALLOGRAFT-REJECTION; RISK-FACTORS; T-CELL; ANTIBODIES; HLA; RECIPIENTS; IMPACT; COMPATIBILITY;
D O I：
10.1159/000253873
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background/Aims: The influence of lymphocytotoxic crossmatch on survival or acute rejection in liver transplantation remains controversial. Data regarding graft survival and acute rejection of living donor liver transplantation ( LDLT) are limited. Methods: We retrospectively examined the influence of a positive T or B lymphocytotoxic cross-match on survival and acute rejection in patients using a database of 414 consecutive LDLT cases. Results: The rejection-free rate at 90 days after LDLT was lower in patients that were T crossmatch-positive compared to patients that were both T and B crossmatch-negative ( 52 vs. 74%, p = 0.03). No patients with a positive lymphocytotoxic crossmatch died due to immunologic causes. The crossmatch results had no effect on graft survival. Conclusion: In the positive crossmatch groups, there was no acute rejection that was untreatable or that caused graft loss. These findings indicate that a positive crossmatch graft should not be considered a contraindication for LDLT. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：482 / 486
页数：5
相关论文
共 50 条
  • [31] PRIOR ESOPHAGEAL VARICEAL BLEEDING DOES NOT ADVERSELY AFFECT SURVIVAL AFTER ORTHOTOPIC LIVER-TRANSPLANTATION
    HO, KS
    LASHNER, BA
    EMOND, JC
    BAKER, AL
    HEPATOLOGY, 1993, 18 (01) : 66 - 72
  • [32] Living donor kidney transplantation in positive crossmatch patients at the Mayo Clinic.
    Gloor, JM
    Larson, TS
    Griffin, MD
    Schwab, TR
    Textor, SC
    Moore, SB
    DeGoey, SR
    Pineda, AA
    Stegall, MD
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 : 10A - 10A
  • [33] Donor Age Does Not Affect Surgical Results after Right Graft Living Donor Liver Transplantation
    Tanemura, Akihiro
    Mizuno, Shugo
    Gyoten, Kazuyuki
    Murata, Yasuhiro
    Kishiwada, Masashi
    Hamada, Takashi
    Usui, Masanobu
    Sakurai, Hiroyuki
    Tabata, Masami
    Isaji, Shuji
    AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 : 273 - 273
  • [34] Significance of Pretransplant False Positive Lymphocytotoxic Crossmatch in Liver Transplant Recipients
    Shin, M.
    Song, S.
    Moon, H. H.
    Lee, S.
    Kim, T. -S
    Kim, J. M.
    Kwon, C. H. D.
    Kim, S. -J
    Joh, J. -W
    Lee, S. -K
    TRANSPLANTATION, 2012, 94 (10) : 396 - 396
  • [35] DO SHARED HLA ANTIGENS BETWEEN PRESENT AND PAST DONORS ADVERSELY AFFECT GRAFT-SURVIVAL IN RECIPIENTS WITH A PAST POSITIVE DONOR CROSSMATCH
    SENITZER, D
    MATAS, AJ
    TELLIS, VA
    VEITH, FJ
    SOBERMAN, R
    TRANSPLANTATION PROCEEDINGS, 1988, 20 (01) : 34 - 36
  • [36] The impact of a positive donor-specific crossmatch on survival after cardiac transplantation
    Likki, S.
    Stehlik, J.
    Fuller, T. C.
    Kfoury, B. G.
    Bader, F.
    Eckels, D.
    Gilbert, E. M.
    Stringham, J. C.
    Hammond, M. E.
    Renlund, D. G.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2006, 25 (02): : S109 - S109
  • [37] Does Timing of Rearterialization of Liver Grafts Affect Biliary Complications in Living and Deceased Donor Liver Transplantation?
    Rammohan, Ashwin
    Govil, Sanjay
    Rela, Mohamed
    LIVER TRANSPLANTATION, 2016, 22 (11) : 1603 - 1606
  • [38] Significance of a T-lymphocytotoxic crossmatch in liver and combined liver-kidney transplantation
    Neumann, UP
    Lang, M
    Moldenhauer, A
    Langrehr, JM
    Glanemann, M
    Kahl, A
    Frei, U
    Bechstein, WO
    Neuhaus, P
    TRANSPLANTATION, 2001, 71 (08) : 1163 - 1168
  • [39] Living Donor Kidney Transplantation Across Positive Crossmatch: The University of Illinois at Chicago Experience
    Thielke, James J.
    West-Thielke, Patricia M.
    Herren, Heather L.
    Bareato, Umberto
    Ommert, Thuy
    Vidanovic, Vladimir
    Campbell-Lee, Sally A.
    Tzvetanov, Ivo G.
    Sankary, Howard N.
    Kaplan, Bruce
    Benedetti, Enrico
    Oberholzer, Jose
    TRANSPLANTATION, 2009, 87 (02) : 268 - 273
  • [40] The effect of a positive T-lymphocytotoxic crossmatch on hepatic allograft survival and rejection
    Bathgate, AJ
    McColl, M
    Garden, OJ
    Forsythe, JLR
    Madhavan, KK
    Hayes, PC
    LIVER TRANSPLANTATION AND SURGERY, 1998, 4 (04): : 280 - 284
12345