Synthesis of (2S, 3R)-2-allyl-3-furyl cyclopentanone.: An enantioselective strategy towards the synthesis of phorbol

被引：7

作者：

Chairgulprasert, V ^{[1
]}

Drew, MGB ^{[1
]}

Jahans, A ^{[1
]}

Harwood, LM ^{[1
]}

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

来源：

ARKIVOC | 2002年

关键词：

chiral; cyclopentenone; phorbol;

D O I：

10.3998/ark.5550190.0003.905

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(1S, 5R)-5-(2-furyl)-2-oxocyclopentanecarboxylate 10 was synthesised by asymmetric conjugate addition of lithium difurylcyanocuprate to the chiral substrate 9 in high diastereoisomeric excess (>95 %). After transesterification, allylation and subsequent decarbomethoxylation, (2S, 3R)-2-allyl-3-furyl cyclopentanone 13 was obtained in >86 % ee.

引用

页码：37 / 45

页数：9

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