Photocatalyst-Free, Visible-Light-Mediated C(sp3)-H Arylation of Amides via a Solvent-Caged EDA Complex

被引：40
|
作者：
Kaur, Jaspreet [1 ]
Shahin, Ahmed [1 ,2 ]
Barham, Joshua P. [1 ]
机构：
[1] Univ Regensburg, Fak Chem & Pharm, D-93040 Regensburg, Germany
[2] Benha Univ, Fac Sci, Chem Dept, Banha 13518, Egypt
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 06期
关键词：
D O I：
10.1021/acs.orglett.1c00132
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A photocatalyst-free and mild visible light photochemical procedure for C(sp(3))-H arylation of amides is described. The reaction proceeds via an electron donor-acceptor (EDA) complex between an electron-rich arene substrate and electron-poor persulfate oxidant. C(sp(3))-H arylation of the amide occurs selectively with the most electron-rich arene of the substrate. Mechanistic studies corroborate the reaction taking place in a solvent cage holding components in a close proximity.
引用
收藏
页码：2002 / 2006
页数：5
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