Synthesis and antifungal activity of 1/3 phenyl-6,7,8,9-tetrahydro[1]benzotheino[3,2-e] [2,3-d]thiazolo[3,2-a]pyrimidin-5(H) ones

被引：0

作者：

Yadav, R. K. ^{[1
]}

Mishra, A. R. ^{[1
]}

Wahab, A. ^{[1
]}

Mishra, R. M. ^{[1
]}

机构：

[1] SDJ Postgrad Coll, Dept Chem, Azangarh 276128, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 16卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

S-Phenacyl-N-(3-carbethoxy-4,5,6,7-tetrahydro-1-benzothien-2-yl) thioureas (la-e) were synthesized by reaction between ethyl-2-amino -4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate and alpha-thiocynoacetophenone. la-e on cyclization gave 3-carbethoxy-2-(2'-imino-4'-phenyl thiazolidin-3'-yl) 4,5,6,7-tetrahydro-1 benzothiophenes (IIa-e) as intermediates which on further cyclization yielded an angular product 1-phenyl-6,7,8,9-tetrahydro [1] benzothieno [3,2-e] thiazolo [3,2-a] pyrimidin -5(H)-one (IVa-e). Similarly Va-e were obtained from IIIa-c. Antifungal activity of the prepared compounds (la-e), (IVa-e) and (Va-e) have been evaluated and compared with Dithan M-45 against Alternaria Solani and Puccinia graminis tritici and the results correlated with their structural features.

引用

页码：305 / 306

页数：2

共 50 条

[31] Synthesis and analgesic activity of 2-arylamino-3-aryl-5-phenyl-thieno [2,3-d] pyrimidin-4 (3H)-ones and 2-arylamino-3-aryl-7-phenyl-thieno [3,2-d] pyrimidin-4 (3H)-ones
Rathod, IS
Patel, HU
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 15 (03) : 271 - 274
[32] Synthesis and characterization of the novel heteroannulated chromeno[2,3-d]pyrimidines and chromeno[2,3-d][1,3]thiazolo[3,2-a] pyrimidines
Ibrahim, Magdy A.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2022, 59 (12) : 2076 - 2083
[33] Design, synthesis and antimicrobial activity of heteroannulated chromeno[3′,2′:5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines
Alshareef, F. M.
Al-Harbi, Sami A.
Allehyani, Esam S.
Abdullah, Omeima
Ibrahim, Magdy A.
SYNTHETIC COMMUNICATIONS, 2024, 54 (02) : 133 - 143
[34] Synthesis and analgesic activity of some novel 2-substituted 1,3,4-thiadiazolo[2,3-b] disubstituted/tetrasubstituted thieno[3,2-e] pyrimidin-5(4H)-ones
Prasad, MR
Pathak, US
Rao, ARR
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2000, 50 (10): : 904 - 909
[35] SYNTHETIC ROUTES TO THIAZOLO[3,2-A]PYRIMIDIN-7-ONES VIA 1-ALLYL-2-THIOURACIL
SKARIC, V
SKARIC, D
CIZMEK, A
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (10): : 2221 - 2225
[36] Synthesis of Substituted 5-Amino-3-(R-carbonyl)-1-(2-oxoethylidene)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e]pyrrolo[1,2-a]pyrimidin-2(1H)-ones with Antinociceptive Activity
Gorbunova, I. A.
Parkhoma, K. Yu.
Makhmudov, R. R.
Shipilovskikh, D. A.
Denislamova, E. S.
Timin, A. S.
Shipilovskikh, S. A.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2024, 94 (04) : 779 - 787
[37] A convenient method of synthesis of 8-acyl-2,3,6,7-tetrahydro-5H-[1,3]thiazolo[3,2-c]pyrimidin-5-ones
Litvinchuk, Mariia B.
Bentya, Anton V.
Slyvka, Nataliia Yu.
Rusanov, Eduard B.
Vovk, Mikhailo V.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2020, 56 (01) : 101 - 107
[38] SYNTHESIS OF 3-SUBSTITUTED 4H-NAPHTHO[1',2-4,5]THIAZOLO-[3,2-A]PYRIMIDIN-4-ONES
LIU, KC
SHIH, BJ
TAO, TM
ARCHIV DER PHARMAZIE, 1985, 318 (01) : 84 - 86
[39] Visible Light Assisted Direct C3-H Arylation of Pyrido[1,2-a]pyrimidin-4-ones and Thiazolo[3,2-a]pyrimidin-5-ones
Bhawale, Rajesh T. T.
Kshirsagar, Umesh A. A.
JOURNAL OF ORGANIC CHEMISTRY, 2023, 88 (13): : 9537 - 9542
[40] Microwave assisted synthesis of 2,3-dihydro-4H-benzo[4,5]thiazolo [3,2-a]furo[2,3-d] pyrimidin-4-ones by radical addition of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a] pyrimidin-4-ones to various conjugated alkenes and dienes mediated Mn(OAc)3
Yilmaz, Mehmet
Inal, Asl i Ustalar
TETRAHEDRON, 2022, 116

← 1 2 3 4 5 →