Synthesis of Functionalized Chiral Imidazole Derivatives Based on a Bornane Skeleton Bearing a Sterically Crowded Spirocyclic Substituent at the C-3 Position

被引：0
|
作者：
Shimada, Kazuaki [1 ]
Fukuma, Kodai [1 ]
Korenaga, Toshinobu [1 ]
机构：
[1] Iwate Univ, Fac Sci & Engn, Dept Chem & Biosci, Morioka, Iwate 0208551, Japan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 09期
关键词：
10-halobornane-2-thione; 10-imidazolylbornane-2-thione; thione S-oxides; 10-imidazolylbornan-2-one; functionalized imidazolium salt; SELENOCARBONYL COMPOUNDS; EFFICIENT SYNTHESIS; CARBONYL-COMPOUNDS; CHARGE-TRANSFER; SULFINES; CAMPHOR; BORNANE-2-THIONES; DIHALOGENS; CHEMISTRY; OXIDATION;
D O I：
10.1177/1934578X19878930
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
10-Imidazolylbornane-2-one bearing a sterically crowded spirocyclic substituent at the C-3 position was prepared from d-camphor through the procedure involving the formation of 10-bromobornane-2-thiones or 10-iodobornane-2-thiones and the subsequent conversion into the corresponding 10-imidazolylbornane-2-thiones followed by an efficient oxidative S-O exchange via thione S-oxides.
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页数：9
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