Gut Microbiota and Extreme Longevity

被引:672
|
作者
Biagi, Elena [1 ]
Franceschi, Claudio [2 ,3 ,4 ]
Rampelli, Simone [1 ]
Severgnini, Marco [5 ]
Ostan, Rita [2 ,3 ]
Turroni, Silvia [1 ]
Consolandi, Clarissa [5 ]
Quercia, Sara [1 ]
Scurti, Maria [2 ,3 ]
Monti, Daniela [6 ]
Capri, Miriam [2 ,3 ]
Brigidi, Patrizia [1 ]
Candela, Marco [1 ]
机构
[1] Univ Bologna, Dept Pharm & Biotechnol, Alma Mater Studiorum, I-40126 Bologna, Italy
[2] Univ Bologna, Alma Mater Studiorum, DIMES Dept Expt Diagnost & Specialty Med, I-40126 Bologna, Italy
[3] Univ Bologna, Alma Mater Studiorum, CIG Interdept Ctr L Galvani, I-40126 Bologna, Italy
[4] Inst Neurol Sci Bologna, IRCCS, I-40139 Bologna, Italy
[5] Natl Res Council ITB CNR, Inst Biomed Technol, I-20090 Milan, Italy
[6] Univ Florence, Dept Clin Expt & Biomed Sci, I-50134 Florence, Italy
关键词
SUBGINGIVAL MICROBIOTA; HEALTH; DIET;
D O I
10.1016/j.cub.2016.04.016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The study of the extreme limits of human lifespan may allow a better understanding of how human beings can escape, delay, or survive the most frequent age-related causes of morbidity, a peculiarity shown by long-living individuals. Longevity is a complex trait in which genetics, environment, and stochasticity concur to determine the chance to reach 100 or more years of age [1]. Because of its impact on human metabolism and immunology, the gut microbiome has been proposed as a possible determinant of healthy aging [2, 3]. Indeed, the preservation of host-microbes homeostasis can counteract inflammaging [4], intestinal permeability [5], and decline in bone and cognitive health [6, 7]. Aiming at deepening our knowledge on the relationship between the gut microbiota and a long-living host, we provide for the first time the phylogenetic microbiota analysis of semi-supercentenarians, i.e., 105-109 years old, in comparison to adults, elderly, and centenarians, thus reconstructing the longest available human microbiota trajectory along aging. We highlighted the presence of a core microbiota of highly occurring, symbiotic bacterial taxa (mostly belonging to the dominant Ruminococcaceae, Lachnospiraceae, and Bacteroidaceae families), with a cumulative abundance decreasing along with age. Aging is characterized by an increasing abundance of subdominant species, as well as a rearrangement in their co-occurrence network. These features are maintained in longevity and extreme longevity, but peculiarities emerged, especially in semi-supercentenarians, describing changes that, even accommodating opportunistic and allochthonous bacteria, might possibly support health maintenance during aging, such as an enrichment and/or higher prevalence of health-associated groups (e.g., Akkermansia, Bifidobacterium, and Christensenellaceae).
引用
收藏
页码:1480 / 1485
页数:6
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