A seronegative case of HIV-1 subtype C infection in Botswana

被引：15
|
作者：
Novitsky, Vladimir
Gaolathe, Tendani
Woldegabriel, Elias
Makhema, Joseph
Essex, M.
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Botswana Harvard Sch Publ Hlth AIDS Initiat Partn, Gaborone, Botswana
[3] Princess Marina Hosp, Infect Dis Care Clin, Gaborone, Botswana
来源：
CLINICAL INFECTIOUS DISEASES | 2007年 / 45卷 / 05期
关键词：
D O I：
10.1086/520683
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We report the first case, to our knowledge, of antibody-negative human immunodeficiency virus type 1 (HIV-1) subtype C infection, which was identified during screening for acute HIV-1 infection in Botswana. Results of tests for HIV-1 antibodies were consistently negative, including rapid and regular enzyme-linked immunosorbent assay and Western blot. The nonrecombinant HIV-1 subtype C infection was confirmed by viral genotyping within the gag, pol, and env genes. The period between referral of the patient in a clinically stable condition and AIDS-related death was similar to 3 months. The reported case indicates the importance of studying the prevalence of seronegative HIV-1 infection in southern Africa, where subtype C predominates.
引用
收藏
页码：E68 / E71
页数：4
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