A seronegative case of HIV-1 subtype C infection in Botswana

被引：15

作者：

Novitsky, Vladimir

Gaolathe, Tendani

Woldegabriel, Elias

Makhema, Joseph

Essex, M.

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Botswana Harvard Sch Publ Hlth AIDS Initiat Partn, Gaborone, Botswana

[3] Princess Marina Hosp, Infect Dis Care Clin, Gaborone, Botswana

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 45卷 / 05期

关键词：

D O I：

10.1086/520683

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the first case, to our knowledge, of antibody-negative human immunodeficiency virus type 1 (HIV-1) subtype C infection, which was identified during screening for acute HIV-1 infection in Botswana. Results of tests for HIV-1 antibodies were consistently negative, including rapid and regular enzyme-linked immunosorbent assay and Western blot. The nonrecombinant HIV-1 subtype C infection was confirmed by viral genotyping within the gag, pol, and env genes. The period between referral of the patient in a clinically stable condition and AIDS-related death was similar to 3 months. The reported case indicates the importance of studying the prevalence of seronegative HIV-1 infection in southern Africa, where subtype C predominates.

引用

页码：E68 / E71

页数：4

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