Single-base Resolution Nucleosome Mapping on DNA Sequences

被引：33

作者：

Gabdank, I. ^{[1
]}

Barash, D. ^{[1
]}

Trifonov, E. N. ^{[2
,3
]}

机构：

[1] Ben Gurion Univ Negev, Dept Comp Sci, IL-84105 Beer Sheva, Israel

[2] Univ Haifa, Genome Divers Ctr, Inst Evolut, IL-31905 Haifa, Israel

[3] Masaryk Univ, Dept Funct Genom & Prote, Inst Expt Biol, Fac Sci, CZ-62500 Brno, Czech Republic

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2010年 / 28卷 / 01期

基金：

以色列科学基金会;

关键词：

Chromatin code; DNA hendability; Nucleosome DNA; Nucleosome positioning; Nucleosome structure; CORE PARTICLE; PAIR DNA; CHROMATIN; ALIGNMENT; CRYSTALS; POSITION; PATTERN; SITES; PITCH;

D O I：

10.1080/07391102.2010.10507347

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleosome DNA bendahility pattern extracted from large nucleosome DNA database of C. elegans is used for construction of full length (116 dinucleotide positions) nucleosome DNA bendahility matrix. The matrix can he used for sequence-directed mapping of the nucleosomes on the sequences. Several alternative positions for a given nucleosome are typically predicted. separated by multiples of nucleosome DNA period. The corresponding computer program is successfully tested on best known experimental examples of accurately positioned nucleosomes. The uncertainty of the computational mapping is +/- 1 base. The procedure is placed on publicly accessible server and can he applied to any DNA sequence of interest.

引用

页码：107 / 121

页数：15

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