Cell migration rate on poly(ε-caprolactone)/poly(ethylene glycol) diblock copolymers and correlation with the material sliding angle

被引：13

作者：

Hsu, Shan-hui ^{[1
]}

Tang, Cheng-Ming

Chiu, Jeng-Jiann

Liao, Tien-Chi

Lin, Chu-Chieh

Iwata, Hiroo

机构：

[1] Natl Chung Hsing Univ, Dept Chem Engn, Taichung 40227, Taiwan

[2] Natl Chung Hsing Univ, Inst Biomed Engn, Taichung 40227, Taiwan

[3] Natl Hlth Res Inst, Div Med Engn Res, Miaoli, Taiwan

[4] Natl Chung Hsing Univ, Dept Chem, Taichung, Taiwan

[5] Kyoto Univ, Inst Frontier Med Sci, Kyoto, Japan

来源：

MACROMOLECULAR BIOSCIENCE | 2007年 / 7卷 / 04期

关键词：

cell migration; microphase separation; nanotopography; PCL/PEG diblock copolymer; sliding angle;

D O I：

10.1002/mabi.200600248

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real-time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate.

引用

页码：482 / 490

页数：9

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