Autologous stem cell transplantation for HIV-associated lymphoma in the antiretroviral and rituximab era: a retrospective study by the EBMT Lymphoma Working Party

被引：13

作者：

Huebl, Kai ^{[1
]}

Re, Alessandro ^{[2
]}

Boumendil, Ariane ^{[3
]}

Finel, Herve ^{[4
]}

Hentrich, Marcus ^{[5
]}

Robinson, Stephen ^{[6
]}

Wyen, Christoph ^{[7
]}

Michieli, Mariagrazia ^{[8
]}

Kanfer, Edward ^{[9
]}

Diez-Martin, Jose Luis ^{[10
]}

Balsalobre, Pascual ^{[10
]}

Vincent, Laure ^{[11
]}

Schroyens, Wilfried ^{[12
]}

Ribera Santasusana, Josep Maria ^{[13
]}

Kroeger, Nicolaus ^{[14
]}

Schiel, Xaver ^{[15
]}

Cwynarski, Kate ^{[16
]}

Esquirol, Albert ^{[17
]}

Sousa, Aida Botelho ^{[18
]}

Cattaneo, Chiara ^{[2
]}

Montoto, Silvia ^{[19
]}

Dreger, Peter ^{[20
]}

机构：

[1] Univ Hosp Cologne, Cologne, Germany

[2] Spedali Civili Brescia, Hematol, Brescia, Italy

[3] CEREST TC, EBMT Paris Study Off, Paris, France

[4] Hop St Antoine, EBMT Paris Study Off, Paris, France

[5] Rotkreuzklinikum Munchen, Munich, Germany

[6] Univ Hosp Bristol NHS Fdn Trust, Bristol, Avon, England

[7] Praxis Ebertpl, Cologne, Germany

[8] Ctr Riferimento Oncol, Aviano, Italy

[9] Hammersmith Hosp London, London, England

[10] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[11] Hosp Ctr Univ, Montpellier, France

[12] Univ Hosp Antwerpen, Antwerp, Belgium

[13] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

[14] Univ Hosp Eppendorf, Hamburg, Germany

[15] Klinikum Harlaching, Munich, Germany

[16] Univ Coll Hosp, London, England

[17] Hosp Santa Creu & Santpau, Barcelona, Spain

[18] Hosp Capuchos, Lisbon, Portugal

[19] Barts Hlth NHS Trust, St Bartholomews Hosp, London, England

[20] Univ Hosp Heidelberg, Heidelberg, Germany

来源：

BONE MARROW TRANSPLANTATION | 2019年 / 54卷 / 10期

关键词：

HIGH-DOSE THERAPY; CLINICAL-PRACTICE GUIDELINES; NON-HODGKIN-LYMPHOMA; PLASMABLASTIC LYMPHOMA; IMMUNODEFICIENCY; RISK; DIAGNOSIS; SURVIVAL; BLOOD;

D O I：

10.1038/s41409-019-0480-x

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The present study aimed at describing the outcome of patients with HIV-associated lymphomas following autologous hematopoietic stem cell transplantation (autoHCT) in the rituximab and combined antiretroviral therapy (cART) era. Eligible for this retrospective study were HIV-positive patients with lymphoma who received autoHCT between 2007 and 2013. A total of 118 patients were included with a median age of 45 years (range 24-66). Underlying diagnoses were diffuse large B cell lymphoma in 47%, Hodgkin lymphoma in 24%, Burkitt lymphoma in 18%, and plasmablastic lymphoma in 7% of patients. Disease status at autoHCT was complete remission in 44%, partial remission (PR) in 38%, and less than PR in 18% of the patients. With a median follow-up of 4 years, 3-year non-relapse mortality, incidence of relapse, progression-free survival (PFS) and overall survival (OS) were 10%, 27%, 63% and 66%, respectively. By multivariate analysis, disease status less than PR but not CD4+ cell count at the time of autoHCT was a significant predictor of unfavorable PFS and OS. In conclusion, in the era of cART and chemoimmunotherapy, the outcome of autoHCT for HIV-related lymphoma is driven by lymphoma-dependent risk factors rather than by characteristics of the HIV infection.

引用

页码：1625 / 1631

页数：7

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