Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of "dimethyl dimethoxy biphenyl dicarboxylate" in male Wistar rats

被引：3
|
作者：
Abdallah, Heba M., I [1 ]
Asaad, Gihan F. [1 ]
Arbid, Mahmoud S. [1 ]
Nomier, Yousra A. [2 ,3 ]
机构：
[1] Natl Res Ctr, Dept Pharmacol, Div Med Sci, Giza, Egypt
[2] Jazan Univ, Pharm Coll, Dept Pharmacol & Toxicol, Jazan, Saudi Arabia
[3] Jazan Univ, Pharm Coll, Dept Pharmacol & Toxicol, POB 114, Jizan 45142, Saudi Arabia
来源：
JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH | 2022年 / 13卷 / 02期
关键词：
Analgesic; antipyretic; antihyperlipidemic; anti-inflammatory; dimethyl dimethoxy biphenyl dicarboxylate; Triton X-100; STEM BARK; DDB;
D O I：
10.4103/japtr.japtr_292_21
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dimethyl dimethoxy biphenyl (DDB) dicarboxylate has been applied as a therapeutic modality for curing liver diseases, particularly hepatitis virus. The objective of this study was to assess the protective potential against Triton X-100 induced abnormal fat metabolism in addition to anti-inflammatory, analgesic, and antipyretic effects of DDB. The anti-inflammatory, antinociceptive, and antipyretic of DDB were investigated through induction of paw edema, pain, and fever in experimental rats. DDB decreased cholesterol and triglyceride contents. DDB resulted in inhibition of inflammation, nociception, and fever in the experimental models. DDB improved lipid profile, as evidence of hypolipidemic potential. It also showed anti-inflammatory, analgesic, and antipyretic properties.
引用
收藏
页码：83 / 88
页数：6
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