Role of Microtubules and Microtubule-Associated Proteins in HIV-1 Infection

被引：41
|
作者：
Dharan, Adarsh [1 ]
Campbell, Edward M. [1 ]
机构：
[1] Loyola Univ Chicago, Stritch Sch Med, Dept Microbiol & Immunol, Maywood, IL 60153 USA
来源：
JOURNAL OF VIROLOGY | 2018年 / 92卷 / 16期
关键词：
BICD2; dynein; EB1; FEZ1; HIV-1; kinesin-1; microtubules; NUCLEAR-PORE COMPLEX; CYTOPLASMIC DYNEIN; STABLE MICROTUBULES; KINESIN-1; ADAPTER; HOST PROTEINS; TRANSPORT; TRAFFICKING; IMPORT; DIFFUSION; DYNAMICS;
D O I：
10.1128/JVI.00085-18
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Recent studies show that human immunodeficiency virus type 1 (HIV-1) can utilize microtubules and their associated proteins to complete key postfusion steps during infection. These include associating with both dynein and kinesin motors, as well as proteins, which enhance infection by altering microtubule dynamics during infection. In this article, we will discuss findings on how dynein and kinesin motors, as well as other microtubule-associated proteins, influence HIV-1 trafficking, viral core uncoating, and nuclear import of the viral ribonucleoprotein (RNP).
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页数：8
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