Synthesis and antitumor activity of novel benzophenone derivatives

被引：0
|
作者：
Kumazawa, E [1 ]
Hirotani, K [1 ]
Burford, SC [1 ]
Kawagoe, K [1 ]
Miwa, T [1 ]
Mitsui, I [1 ]
Ejima, A [1 ]
机构：
[1] DAIICHI PHARMACEUT CO LTD, NEW PROD RES LABS 3, EDOGAWA KU, TOKYO 134, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1997年 / 45卷 / 09期
关键词：
benzophenone; cytotoxic activity; antitumor activity;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a. 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.
引用
收藏
页码：1470 / 1474
页数：5
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