Correlation of Alzheimer's Disease with Wnt Signaling Pathway and Neural Stem Cells

被引：0
|
作者：
Yao, Hongbo [1 ]
Sun, Lihui [1 ]
Lian, Jie [1 ]
Zhang, Meng [1 ]
Liu, Danyang [1 ]
机构：
[1] Qiqihaer Med Univ, Qiqihaer City 161006, Jianhua Distric, Peoples R China
来源：
PROCEEDINGS OF THE 4TH INTERNATIONAL CONFERENCE ON MECHATRONICS, MATERIALS, CHEMISTRY AND COMPUTER ENGINEERING 2015 (ICMMCCE 2015) | 2015年 / 39卷
关键词：
Alzheimer's Disease; Wnt Signaling Pathway; Neural Stem Cells; PROLIFERATION;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Recent studies have shown that Wnt signaling molecules and the occurrence and development of Alzheimer's disease are closely related. Wnt protein secretion by autocrine or located next to the cell membrane receptor binding, activation of intracellular signaling pathways to regulate expression of target genes of cell proliferation during embryonic development, differentiation, migration, polarity and apoptosis has played an important role. The pathological mechanism of Alzheimer's disease involves inherited, environmental and immunological factors. Strong evidence exists that Wnt signaling pathway is closely related to the pathological process of Alzheimer's disease. There is also evidence that Wnt signaling pathway plays a crucial effect on the proliferation of neural stem cells. To review the relationship between pathological process of Alzheimer's disease and Wnt signaling pathway and effects of Wnt signaling on proliferation and differentiation of neural stem cells, providing theoretical evidence for treatment of Alzheimer's disease.
引用
收藏
页码：119 / 122
页数：4
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