CYP2D activity in the brain acts independently from CYP2D in the liver to alter CNS drug levels and response

被引：0
|
作者：
Tyndale, R. [1 ,2 ,3 ]
Miksys, S. [1 ,2 ]
机构：
[1] Univ Toronto, Toronto, ON, Canada
[2] CAMH, Dept Pharmacol & Toxicol, Toronto, ON, Canada
[3] CAMH, Dept Psychiat, Toronto, ON, Canada
来源：
EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2016年 / 26卷
关键词：
INDUCTION;
D O I：
10.1016/S0924-977X(16)30885-9
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
S.05.03
引用
收藏
页码：S119 / S119
页数：1
相关论文
共 50 条
  • [21] Chronic treatment with iloperidone affects the cytochrome P450 2D (CYP2D) protein and activity in the brain and liver
    Danek, P. J.
    Daniel, W. A.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2021, 53 : S412 - S413
  • [22] Complex gene expansion of the CYP2D gene subfamily
    Feng, Ping
    Liu, Zhijun
    ECOLOGY AND EVOLUTION, 2018, 8 (22): : 11022 - 11030
  • [23] Catalytic specificity of CYP2D isoforms in rat and human
    Hiroi, T
    Chow, T
    Imaoka, S
    Funae, Y
    DRUG METABOLISM AND DISPOSITION, 2002, 30 (09) : 970 - 976
  • [24] A retroviral element in the human CYP2D gene cluster
    Molven, A
    Steen, VM
    PHARMACOGENETICS, 1996, 6 (04): : 375 - 377
  • [25] Inhibition of CYP2D activity by the constituents of Oren-gedoku-to in rats
    Nishimura, Yuki
    Kurata, Norimitsu
    Iwase, Mariko
    Yasuhara, Hajime
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106 : 253P - 253P
  • [26] Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses
    Tolledo, Edgor Cole
    Miksys, Sharon
    Gonzalez, Frank J.
    Tyndale, Rachel F.
    BRITISH JOURNAL OF PHARMACOLOGY, 2020, 177 (03) : 701 - 712
  • [27] Effect of acute and repeated administration of methamphetamine on the activity of CYP2D in isolated perfused rat liver
    Dostálek, M
    Pistovcáková, J
    Minaríková, V
    Jurica, J
    Tomandl, J
    Hadasová, E
    ACTA VETERINARIA BRNO, 2005, 74 (03) : 339 - 345
  • [28] Distribution of CYP2D activity in the brain and dopamine formation - Implications for Parkinson's disease.
    Bromek, E.
    Haduch, A.
    Daniel, W. A.
    BEHAVIOURAL PHARMACOLOGY, 2006, 17 (5-6): : 544 - 545
  • [29] CYP2D plays a major role in berberine metabolism in liver of mice and humans
    Guo, Ying
    Li, Feng
    Ma, Xiaochao
    Cheng, Xingguo
    Zhou, Honghao
    Klaassen, Curtis D.
    XENOBIOTICA, 2011, 41 (11) : 996 - 1005
  • [30] Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders
    Woo, SI
    Hansen, LA
    Yu, X
    Mallory, M
    Masliah, E
    NEUROLOGY, 1999, 53 (07) : 1570 - 1572
12345