The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization

被引：38

作者：

Zou, Jing ^{[1
]}

Xie, Xuping ^{[1
]}

Fontes-Garfias, Camila R. ^{[1
]}

Swanson, Kena A. ^{[2
]}

Kanevsky, Isis ^{[2
]}

Tompkins, Kristin ^{[2
]}

Cutler, Mark ^{[2
]}

Cooper, David ^{[2
]}

Dormitzer, Philip R. ^{[2
]}

Shi, Pei-Yong ^{[1
,3
,4
,5
]}

机构：

[1] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

[2] Pfizer, Pearl River, NY 10965 USA

[3] Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA

[4] Univ Texas Med Branch, Sealy Inst Vaccine Sci, Galveston, TX 77555 USA

[5] Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA

来源：

NPJ VACCINES | 2021年 / 6卷 / 01期

关键词：

D O I：

10.1038/s41541-021-00313-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.

引用

页数：4

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