Perspectives of Liquid Chromatography Coupled to Low- and High-Resolution Mass Spectrometry for Screening, Identification, and Quantification of Drugs in Clinical and Forensic Toxicology

被引：55

作者：

Maurer, Hans H. ^{[1
]}

机构：

[1] Univ Saarland, Dept Expt & Clin Toxicol, Inst Expt & Clin Pharmacol & Toxicol, D-66421 Homburg, Saar, Germany

来源：

THERAPEUTIC DRUG MONITORING | 2010年 / 32卷 / 03期

关键词：

LC-MS/MS; screening; quantification; clinical toxicology; forensic toxicology; REACTION-MONITORING MODE; LC-MS-MS; HUMAN URINE; DIRECT-INJECTION; DESIGNER DRUGS; DOPING CONTROL; ILLICIT DRUGS; ORAL FLUID; METABOLISM; ABUSE;

D O I：

10.1097/FTD.0b013e3181dca295

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

This article reviews papers on the use of liquid chromatography coupled to low- and high-resolution mass spectrometry in clinical and forensic toxicology. They cover procedures for target and for more comprehensive screening for drugs (of abuse), identification of drug metabolites, and multianalyte procedures for quantification of drugs and/or their metabolites in body samples. Besides a critical overview, perspectives are discussed.

引用

页码：324 / 327

页数：4

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