Association of HLA-DRB1*09:01 with severe COVID-19

被引：38

作者：

Anzurez, Alitzel ^{[1
,2
]}

Naka, Izumi ^{[3
]}

Miki, Shoji ^{[1
]}

Nakayama-Hosoya, Kaori ^{[1
]}

Isshiki, Mariko ^{[3
]}

Watanabe, Yusuke ^{[3
]}

Nakamura-Hoshi, Midori ^{[1
]}

Seki, Sayuri ^{[1
]}

Matsumura, Takayuki ^{[4
]}

Takano, Tomohiro ^{[4
]}

Onodera, Taishi ^{[4
]}

Adachi, Yu ^{[4
]}

Moriyama, Saya ^{[4
]}

Terahara, Kazutaka ^{[4
]}

Tachikawa, Natsuo ^{[5
]}

Yoshimura, Yoshihiro ^{[5
]}

Sasaki, Hiroaki ^{[5
]}

Horiuchi, Hiroshi ^{[5
]}

Miyata, Nobuyuki ^{[5
]}

Miyazaki, Kazuhito ^{[5
]}

Koga, Michiko ^{[6
]}

Ikeuchi, Kazuhiko ^{[6
]}

Nagai, Hiroyuki ^{[6
]}

Saito, Makoto ^{[6
]}

Adachi, Eisuke ^{[6
]}

Yotsuyanagi, Hiroshi ^{[6
]}

Kutsuna, Satoshi ^{[7
]}

Kawashima, Akira ^{[7
]}

Miyazato, Yusuke ^{[7
]}

Kinoshita, Noriko ^{[7
]}

Kouno, Chiyoko ^{[8
]}

Tanaka, Kensuke ^{[8
]}

Takahashi, Yoshimasa ^{[4
]}

Suzuki, Tadaki ^{[9
]}

Matano, Tetsuro ^{[1
,2
,10
]}

Ohashi, Jun ^{[3
]}

Kawana-Tachikawa, Ai ^{[1
,2
,10
]}

机构：

[1] Natl Inst Infect Dis, AIDS Res Ctr, Tokyo, Japan

[2] Kumamoto Univ, Joint Res Ctr Human Retrovirus Infect, Kumamoto, Japan

[3] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo, Japan

[4] Natl Inst Infect Dis, Dept Immunol, Tokyo, Japan

[5] Yokohama Municipal Citizens Hosp, Dept Infect Dis, Yokohama, Kanagawa, Japan

[6] Univ Tokyo, Adv Clin Res Ctr, Inst Med Sci, Div Infect Dis, Tokyo, Japan

[7] Natl Ctr Global Hlth & Med, Dis Control & Prevent Ctr, Tokyo, Japan

[8] JR Tokyo Gen Hosp, Tokyo, Japan

[9] Natl Inst Infect Dis, Dept Pathol, Tokyo, Japan

[10] Univ Tokyo, Inst Med Sci, Dept AIDS Vaccine Dev, Tokyo, Japan

来源：

HLA | 2021年 / 98卷 / 01期

关键词：

association; coronavirus disease 2019; human leukocyte antigen; Japan; risk factor; severe acute respiratory syndrome coronavirus 2;

D O I：

10.1111/tan.14256

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID-19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID-19.

引用

页码：37 / 42

页数：6

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