Single-molecule technology for rapid detection of DNA hybridization based on resonance light scattering of gold nanoparticles

被引：63
|
作者：
Wang, Kanglin [1 ]
Qiu, Xin [1 ]
Dong, Chaoqing [1 ]
Ren, Jicun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China
来源：
CHEMBIOCHEM | 2007年 / 8卷 / 10期
关键词：
DNA; gold; nanostructures; single-molecule studies;
D O I：
10.1002/cbic.200700174
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(Graph Presented) All that scatters... A single-molecule detection technique, named resonance light-scattering correlation spectroscopy, has been developed based on the extremely strong resonance light scattering of gold nanoparticles. This technology was successfully used to determine the size of gold nanoparticles, and to rapidly detect solution-phase DNA hybridization. Complementary and single-base mismatch oligonucleotides could be distinguished within 5 min. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1126 / 1129
页数：4
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