A novel HPQ-based turn-on fluorescent probe for detection of fluoride ions in living cells

被引：24
|
作者：
Zhao, Zhou [1 ]
Bi, Xinzhou [2 ]
Mao, Wuxiang [3 ]
Xu, Xiaowei [1 ]
机构：
[1] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[3] Hubei Univ, Hubei Collaborat Innovat Ctr Green Transformat Bi, Coll Life Sci, Wuhan 430062, Hubei, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 43期
关键词：
HPQ; Fluoride; Fluorescence probe; BETA-GLUCURONIDASE; NAKED-EYE; FLUOROPHORE; LUMINESCENCE; OSTEOPOROSIS; RECOGNITION; SUBSTRATE; WATER; DOTS;
D O I：
10.1016/j.tetlet.2017.09.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-(2'-Hydroxyphenyl)-4(3H)-quinazolinone (HPQ) has been reported as a precipitating fluorescent molecule with excellent optical properties, such as large Stokes shift and strong fluorescence intensity. HPQF, a novel HPQ-based turn-on probe for localizable detection of fluoride ions, was designed, synthesized and fully characterized by H-1 NMR, C-13 NMR and HRMS. As a chemogenic fluoride probe, the tertbutyldiphenylsilane moiety of HPQF can be easily cleaved by fluoride. After spontaneous 1,6-elimination, HPQ molecule was generated to emit fluorescence under the excitation light. Further study shows that HPQF exhibited high selectivity and sensitivity for detection of fluoride. In addition, HPQF was utilized for the detection of fluoride in living cells. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4129 / 4132
页数：4
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