Sumalactones A-D, four new curvularin-type macrolides from a marine deep sea fungus Penicillium Sumatrense

被引：19
|
作者：
Wu, Yue-Hua [1 ]
Zhang, Zhi-Han [1 ]
Zhong, Yue [1 ]
Huang, Jun-Jun [2 ]
Li, Xiao-Xia [1 ]
Jiang, Jin-Yan [1 ]
Deng, Yin-Yue [1 ,3 ]
Zhang, Lian-Hui [1 ]
He, Fei [1 ]
机构：
[1] South China Agr Univ, Coll Agr, Integrat Microbiol Res Ctr, Guangzhou 510642, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Sch Pharmacol, Pharmaceut Res Ctr, Guangzhou 510182, Guangdong, Peoples R China
[3] South China Agr Univ, Guangdong Innovat & Entrepreneurial Res Team Soci, Guangzhou 510642, Guangdong, Peoples R China
来源：
RSC ADVANCES | 2017年 / 7卷 / 63期
基金：
中国国家自然科学基金;
关键词：
ABSOLUTE-CONFIGURATIONS; BETA-DEHYDROCURVULARIN; XESTODECALACTONE-A; INDOLE ALKALOIDS; BIOSYNTHESIS; METABOLITES; ASSIGNMENT; LACTONES; ALPHA;
D O I：
10.1039/c7ra06933b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sumalactones A-D (1-4), four new curvularin-type macrolides, together with two known analogues, curvularin (5) and dehydrocurvularin (6), were isolated from Penicillium Sumatrense, a marine fungus isolated from deep-sea sediments. Sumalactones C (3) and D (4) are unprecedented curvularin-type macrolides bearing a rare 11-membered macrolide skeleton. Their structures were elucidated on the basis of intensive spectroscopic analysis. The absolute configurations of compounds 1-4 were determined by CD spectra and modified Mosher's method. Compound 6 showed significant inhibition activity towards LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 value of 0.91 mu M.
引用
收藏
页码：40015 / 40019
页数：5
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