Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0

被引：54
|
作者：
Naldi, Aurelien [1 ]
Hernandez, Celine [1 ]
Abou-Jaoude, Wassim [1 ]
Monteiro, Pedro T. [2 ]
Chaouiya, Claudine [3 ]
Thieffry, Denis [1 ]
机构：
[1] PSL Univ, INSERM, IBENS, Computat Syst Biol Team,Ecole Normale Super,CNRS, Paris, France
[2] Univ Lisbon, Inst Super Tecn, INESC ID, Lisbon, Portugal
[3] Inst Gulbenkian Ciencias, Oeiras, Portugal
来源：
FRONTIERS IN PHYSIOLOGY | 2018年 / 9卷
关键词：
regulatory network; logical model; discrete dynamics; regulatory circuit; p53-Mdm2; network; DYNAMICAL BEHAVIOR; FLY EMBRYO; P53; MDM2; REPRESENTATION; OSCILLATIONS;
D O I：
10.3389/fphys.2018.00646
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.
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页数：16
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