Circulating Fatty Acids and Prostate Cancer Risk: Individual Participant Meta-Analysis of Prospective Studies

被引：44

作者：

Crowe, Francesca L. ^{[1
]}

Appleby, Paul N. ^{[1
]}

Travis, Ruth C. ^{[1
]}

Barnett, Matt ^{[2
]}

Brasky, Theodore M. ^{[3
]}

Bueno-de-Mesquita, H. Bas ^{[4
,5
,6
]}

Chajes, Veronique ^{[7
,8
]}

Chavarro, Jorge E. ^{[9
,10
,11
,12
,13
]}

Chirlaque, Maria-Dolores ^{[14
,15
]}

English, Dallas R. ^{[16
,17
]}

Gibson, Robert A. ^{[18
]}

Giles, Graham G. ^{[16
,17
]}

Goodman, Gary E. ^{[2
]}

Henning, Susanne M. ^{[19
]}

Kaaks, Rudolf ^{[20
]}

King, Irena B. ^{[2
,21
]}

Kolonel, Lawrence N. ^{[22
]}

Kristal, Alan R. ^{[23
]}

Neuhouser, Marian L. ^{[2
]}

Park, Song-Yi ^{[22
]}

Severi, Gianluca ^{[16
,17
]}

Siddiq, Afshan ^{[24
]}

Stampfer, Meir J. ^{[9
,10
,11
,12
,13
]}

Stattin, Paer ^{[25
]}

Tangen, Catherine M. ^{[23
]}

Tjonneland, Anne ^{[26
]}

Trichopoulos, Dimitrios ^{[10
,27
,28
]}

Tumino, Rosario ^{[29
]}

Wilkens, Lynne R. ^{[22
]}

Key, Timothy J. ^{[1
]}

Allen, Naomi E. ^{[30
,31
]}

机构：

[1] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England

[2] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[3] Ohio State Univ, Coll Med, Dept Internal Med, Div Canc Prevent & Control, Columbus, OH 43210 USA

[4] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[5] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[6] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[7] Int Agcy Res Canc, Nutr & Metab Sect, F-69372 Lyon, France

[8] Int Agcy Res Canc, Nutr Epidemiol Grp, F-69372 Lyon, France

[9] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[10] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[11] Channing Div Network Med, Boston, MA USA

[12] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[13] Harvard Univ, Sch Med, Boston, MA USA

[14] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[15] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[16] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia

[17] Univ Melbourne, Sch Populat Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3010, Australia

[18] Univ Adelaide, FOODplus Res Ctr, Glen Osmond, SA, Australia

[19] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Human Nutr, Los Angeles, CA 90095 USA

[20] German Canc Res Ctr, Dept Canc Epidemiol, Heidelberg, Germany

[21] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA

[22] Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96822 USA

[23] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, Seattle, WA 98104 USA

[24] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Genom Common Dis, London, England

[25] Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden

[26] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[27] Acad Athens, Bur Epidemiol Res, Athens, Greece

[28] Hellen Hlth Fdn, Athens, Greece

[29] Civ & MP Arezzo Hosp, Canc Registry & Histopathol Unit, Asp Ragusa, Italy

[30] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

[31] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2014年 / 106卷 / 09期

基金：

美国国家卫生研究院;

关键词：

C-REACTIVE PROTEIN; PLASMA PHOSPHOLIPIDS; MORTALITY; BLOOD; TRIAL; PROGRESSION; BIOMARKERS; HORMONES; INSULIN; SMOKERS;

D O I：

10.1093/jnci/dju240

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Individual studies have suggested that some circulating fatty acids are associated with prostate cancer risk, but have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease. Methods Principal investigators of prospective studies on circulating fatty acids and prostate cancer were invited to collaborate. Investigators provided individual participant data on circulating fatty acids (weight percent) and other characteristics of prostate cancer cases and controls. Prostate cancer risk by study-specific fifths of 14 fatty acids was estimated using multivariable-adjusted conditional logistic regression. All statistical tests were two-sided. Results Five thousand and ninety-eight case patients and 6649 control patients from seven studies with an average follow-up of 5.1 (SD = 3.3) years were included. Stearic acid (18: 0) was inversely associated with total prostate cancer (odds ratio [OR] Q5 vs Q1 = 0.88, 95% confidence interval [CI] = 0.78 to 1.00, P-trend = .043). Prostate cancer risk was, respectively, 14% and 16% greater in the highest fifth of eicosapentaenoic acid (20:5n-3) (OR = 1.14, 95% CI = 1.01 to 1.29, P-trend = .001) and docosapentaenoic acid (22: 5n-3) (OR = 1.16, 95% CI = 1.02 to 1.33, P-trend = .003), but in each case there was heterogeneity between studies (P = .022 and P < .001, respectively). There was heterogeneity in the association between docosapentaenoic acid and prostate cancer by grade of disease (P = .006); the association was statistically significant for low-grade disease but not high-grade disease. The remaining 11 fatty acids were not statistically associated with total prostate cancer risk. Conclusion There was no strong evidence that circulating fatty acids are important predictors of prostate cancer risk. It is not clear whether the modest associations of stearic, eicosapentaenoic, and docosapentaenoic acid are causal.

引用

页数：10

共 50 条

[1] Vasectomy and prostate cancer risk: a meta-analysis of prospective studies
Cheng, Sheng
Yang, Bo
Xu, Liwei
Zheng, Qiming
Ding, Guoqing
Li, Gonghui
CARCINOGENESIS, 2021, 42 (01) : 31 - 37
[2] A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk
Travis, Ruth C.
Perez-Cornago, Aurora
Appleby, Paul N.
Albanes, Demetrius
Joshu, Corinne E.
Lutsey, Pamela L.
Mondul, Alison M.
Platz, Elizabeth A.
Weinstein, Stephanie J.
Layne, Tracy M.
Helzlsouer, Kathy J.
Visvanathan, Kala
Palli, Domenico
Peeters, Petra H.
Bueno-de-Mesquita, Bas
Trichopoulou, Antonia
Gunter, Marc J.
Tsilidis, Konstantinos K.
Sanchez, Maria-Jose
Olsen, Anja
Brenner, Hermann
Schoettker, Ben
Perna, Laura
Holleczek, Bernd
Knekt, Paul
Rissanen, Harri
Yeap, Bu B.
Flicker, Leon
Almeida, Osvaldo P.
Wong, Yuen Yee Elizabeth
Chan, June M.
Giovannucci, Edward L.
Stampfer, Meir J.
Ursin, Giske
Gislefoss, Randi E.
Bjorge, Tone
Meyer, Haakon E.
Blomhoff, Rune
Tsugane, Shoichiro
Sawada, Norie
English, Dallas R.
Eyles, Darryl W.
Heath, Alicia K.
Williamson, Elizabeth J.
Manjer, Jonas
Malm, Johan
Almquist, Martin
Le Marchand, Loic
Haiman, Christopher A.
Wilkens, Lynne R.
CANCER RESEARCH, 2019, 79 (01) : 274 - 285
[3] Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants
Borges, Maria Carolina
Schmidt, Amand Floriaan
Jefferis, Barbara
Wannamethee, S. Goya
Lawlor, Debbie A.
Kivimaki, Mika
Kumari, Meena
Gaunt, Tom R.
Ben-Shlomo, Yoav
Tillin, Therese
Menon, Usha
Providencia, Rui
Dale, Caroline
Gentry-Maharaj, Aleksandra
Hughes, Alun
Chaturvedi, Nish
Casas, Juan Pablo
Hingorani, Aroon D.
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (05):
[4] Effect of Individual Omega-3 Fatty Acids on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
Fu, Yuan-Qing
Zheng, Ju-Sheng
Yang, Bo
Li, Duo
JOURNAL OF EPIDEMIOLOGY, 2015, 25 (04) : 261 - 274
[5] A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
Travis, Ruth C.
Appleby, Paul N.
Martin, Richard M.
Holly, Jeff M. P.
Albanes, Demetrius
Black, Amanda
Bueno-de-Mesquita, H. Bas
Chan, June M.
Chen, Chu
Chirlaque, Maria-Dolores
Cook, Michael B.
Deschasaux, Melanie
Donovan, Jenny L.
Ferrucci, Luigi
Galan, Pilar
Giles, Graham G.
Giovannucci, Edward L.
Gunter, Marc J.
Habel, Laurel A.
Hamdy, Freddie C.
Helzlsouer, Kathy J.
Hercberg, Serge
Hoover, Robert N.
Janssen, Joseph A. M. J. L.
Kaaks, Rudolf
Kubo, Tatsuhiko
Le Marchand, Loic
Metter, E. Jeffrey
Mikami, Kazuya
Morris, Joan K.
Neal, David E.
Neuhouser, Marian L.
Ozasa, Kotaro
Palli, Domenico
Platz, Elizabeth A.
Pollak, Michael N.
Price, Alison J.
Roobol, Monique J.
Schaefer, Catherine
Schenk, Jeannette M.
Severi, Gianluca
Stampfer, Meir J.
Stattin, Par
Tamakoshi, Akiko
Tangen, Catherine M.
Touvier, Mathilde
Wald, Nicholas J.
Weiss, Noel S.
Ziegler, Regina G.
Key, Timothy J.
CANCER RESEARCH, 2016, 76 (08) : 2288 - 2300
[6] Re: Effect of Individual Omega-3 Fatty Acids on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
Tokudome, Shinkan
JOURNAL OF EPIDEMIOLOGY, 2015, 25 (08) : 559 - 560
[7] ISOFLAVONES, LIGNANS AND PROSTATE CANCER RISK: AN ANALYSIS OF INDIVIDUAL PARTICIPANT DATA FROM 5 PROSPECTIVE STUDIES
Perez-Cornago, Aurora
ANNALS OF NUTRITION AND METABOLISM, 2017, 71 : 686 - 687
[8] Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies
Cao, Yi
Hou, Lin
Wang, Weijing
INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (08) : 1894 - 1904
[9] Circulating vitamin D concentration and risk of prostate cancer: a dose-response meta-analysis of prospective studies
Gao, Jialin
Wei, Wei
Wang, Gang
Zhou, Honglan
Fu, Yaowen
Liu, Nian
THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2018, 14 : 95 - 103
[10] Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis
Brasky, Theodore M.
Hade, Erinn M.
Cohn, David E.
Newton, Alison M.
Petruzella, Stacey
O'Connell, Kelli
Bertrand, Kimberly A.
Cook, Linda S.
De Vivo, Immaculata
Du, Mengmeng
Freudenheim, Jo L.
Friedenreich, Christine M.
Goodman, Marc T.
Gorzelitz, Jessica
Ibiebele, Torukiri I.
Krogh, Vittorio
Liao, Linda M.
Lipworth, Loren
Lu, Lingeng
McCann, Susan
O'Mara, Tracy A.
Palmer, Julie R.
Ponte, Jeanette
Prizment, Anna
Risch, Harvey
Sandin, Sven
Schouten, Leo J.
Setiawan, Veronica Wendy
Shu, Xiao-ou
Trabert, Britton
Brandt, Piet A. van den
Webb, Penelope M.
Wentzensen, Nicolas
Wilkens, Lynne R.
Wolk, Alicja
Yu, Herbert
Neuhouser, Marian L.
GYNECOLOGIC ONCOLOGY, 2023, 169 : 137 - 146

← 1 2 3 4 5 →