Synthesis of 1,1-Disubstituted N-Acyl Tetrahydroisoquinolines from Enamides by Cascade Radical Addition and Cyclization

被引：7

作者：

Yu, Hui ^{[1
]}

Xuan, Pengfei ^{[1
]}

Jiao, Mingdong ^{[1
]}

Lin, Jingbo ^{[1
]}

机构：

[1] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Substainabil, 1239 Siping Rd, Shanghai 200092, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 33期

关键词：

Radicals; Cyclization; Nitrogen heterocycles; Enamides; Benzylation; ACTIVATED ALKENES; HIGHLY EFFICIENT; ACRYLAMIDES; DERIVATIVES; BENZAMIDES; CARBOTRIFLUOROMETHYLATION; DIFUNCTIONALIZATION; FUNCTIONALIZATION; ALKYLARYLATION; CONSTRUCTION;

D O I：

10.1002/ejoc.201800748

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper(I)-catalyzed radical 1,2-benzylarylation of N-phenethylenamides was developed and 1,1-disubstituted N-acyl tetrahydroisoquinolines were obtained in moderate to good yields. In this process, two new C-C bonds were formed in one-step fashion with high atom economy. A possible reaction pathway for the formation of the products is also discussed.

引用

页码：4565 / 4570

页数：6

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