Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

被引：52

作者：

Leenders, Max ^{[1
,2
]}

Leufkens, Anke M. ^{[1
,3
]}

Siersema, Peter D. ^{[1
]}

van Duijnhoven, Franzel J. B. ^{[3
,4
]}

Vrieling, Alina ^{[3
,5
]}

Hulshof, Paul J. M. ^{[4
]}

van Gils, Carla H. ^{[6
]}

Overvad, Kim ^{[7
]}

Roswall, Nina ^{[8
]}

Kyro, Cecilie ^{[8
]}

Boutron-Ruault, Marie-Christine ^{[9
,10
,11
]}

Fagerhazzi, Guy ^{[9
,10
,11
]}

Cadeau, Claire ^{[9
,10
,11
]}

Kuehn, Tilman ^{[12
]}

Johnson, Theron ^{[12
]}

Boeing, Heiner ^{[13
]}

Aleksandrova, Krasimira ^{[13
]}

Trichopoulou, Antonia ^{[14
,15
]}

Klinaki, Eleni ^{[14
]}

Androulidaki, Anna ^{[14
]}

Palli, Domenico ^{[16
]}

Grioni, Sara ^{[17
]}

Sacerdote, Carlotta ^{[18
,19
]}

Tumino, Rosario ^{[20
,21
]}

Panico, Salvatore ^{[22
]}

Bakker, Marije F. ^{[6
]}

Skeie, Guri ^{[23
]}

Weiderpass, Elisabete ^{[23
,24
,25
,26
]}

Jakszyn, Paula ^{[27
]}

Barricarte, Aurelio ^{[28
,29
]}

Maria Huerta, Jose ^{[29
,30
]}

Molina-Montes, Esther ^{[29
,31
]}

Argueelles, Marcial ^{[32
]}

Johansson, Ingegerd ^{[33
]}

Ljuslinder, Ingrid ^{[34
]}

Key, Timothy J. ^{[35
]}

Bradbury, Kathryn E. ^{[35
]}

Khaw, Kay-Tee ^{[36
]}

Wareham, Nicholas J. ^{[36
]}

Ferrari, Pietro ^{[37
]}

Duarte-Salles, Talita ^{[37
]}

Jenab, Mazda ^{[37
]}

Gunter, Marc J. ^{[38
]}

Vergnaud, Anne-Claire ^{[38
]}

Wark, Petra A. ^{[38
]}

Bueno-de-Mesquita, H. B ^{[1
,3
,38
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[2] Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TC Utrecht, Netherlands

[3] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[4] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Hlth Evidence, Nijmegen, Netherlands

[6] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[7] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[8] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[9] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, U1018, Nutr Hormones & Womens Hlth Team, Villejuif, France

[10] Univ Paris 11, UMRS 1018, Villejuif, France

[11] Inst Gustave Roussy, Villejuif, France

[12] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[13] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[14] Hellen Hlth Fdn, Athens, Greece

[15] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[16] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[17] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[18] Ctr Canc Prevent CPO Piemonte, Turin, Italy

[19] Human Genet Fdn HuGeF, Turin, Italy

[20] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[21] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[22] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[23] Univ Tromso, Fac Hlth Sci, Dept Community Med, Arctic Univ Norway, Tromso, Norway

[24] Canc Registry Norway, Dept Res, Oslo, Norway

[25] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[26] Samfundet Folkhalsan, Helsinki, Finland

[27] Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[28] Navarre Publ Hlth Inst, Pamplona, Spain

[29] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona, Spain

[30] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[31] Andalusian Sch Publ Hlth, Granada, Spain

[32] Publ Hlth Directorate, Asturias, Spain

[33] Umea Univ, Dept Odontol, S-90187 Umea, Sweden

[34] Umea Univ, Dept Radiat Sci, S-90187 Umea, Sweden

[35] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford OX1 2JD, England

[36] Univ Cambridge, Cambridge CB2 1TN, England

[37] Int Agcy Res Canc IARC WHO, Lyon, France

[38] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London SW7 2AZ, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2014年 / 135卷 / 12期

基金：

英国医学研究理事会;

关键词：

carotenoids; vitamins; antioxidants; colorectal cancer; fruits and vegetables; SERUM ALPHA-TOCOPHEROL; COLORECTAL-CANCER; OXIDATIVE STRESS; PHYSICAL-ACTIVITY; EPIC PROJECT; ANTIOXIDANTS; RETINOL; HEALTH; COHORT; BIOMARKERS;

D O I：

10.1002/ijc.28938

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Carotenoids and vitamins A, C and E are possibly associated with a reduced colorectal cancer (CRC) risk through antioxidative properties. The association of prediagnostic plasma concentrations and dietary consumption of carotenoids and vitamins A, C and E with the risk of colon and rectal cancer was examined in this case-control study, nested within the European Prospective Investigation into Cancer and Nutrition study. Plasma concentrations of carotenoids (alpha- and beta-carotene, canthaxanthin, beta-cryptoxanthin, lutein, lycopene, zeaxanthin) and vitamins A (retinol), C and E (alpha-, beta- and gamma-and delta-tocopherol) and dietary consumption of beta-carotene and vitamins A, C and E were determined in 898 colon cancer cases, 501 rectal cancer cases and 1,399 matched controls. Multivariable conditional logistic regression models were performed to estimate incidence rate ratios (IRR) and corresponding 95% confidence intervals (CIs). An association was observed between higher prediagnostic plasma retinol concentration and a lower risk of colon cancer (IRR for highest quartile = 0.63, 95% CI: 0.46, 0.87, p for trend = 0.01), most notably proximal colon cancer (IRR for highest quartile = 0.46, 95% CI: 0.27, 0.77, p for trend = 0.01). Additionally, inverse associations for dietary beta-carotene and dietary vitamins C and E with (distal) colon cancer were observed. Although other associations were suggested, there seems little evidence for a role of these selected compounds in preventing CRC through their antioxidative properties.

引用

页码：2930 / 2939

页数：10

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